Particles including degradable material and anti-microbial agent

Patent 5616315 Issued on April 1, 1997. Estimated Expiration Date:

October 13, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Re24899

3523906

3699979

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Inventors

Assignee

Gillette Canada Inc.

Application

No. 322926 filed on 10/13/1994

US Classes:

424/54, Ammonia, amine, or derivative thereof (e.g., urea, etc.)424/401, Cosmetic, antiperspirant, dentifrice424/490, Coated (e.g., microcapsules)424/497, Containing solid synthetic polymers424/501Contains solid synthetic resin

Examiners

Primary: Geist, Gary
Assistant: Williams, Rosalynd A.

Attorney, Agent or Firm

Fish & Richardson P.C.

Foreign Patent References

0244118 EP 11/12/1987
WO92/20319 WO. 11/12/1992
WO93/05680 WO. 04/12/1993
WO93/11754 WO. 06/12/1993
WO94/08562 WO. 04/12/1994
94/08562 WO. 04/12/1994

International Class

A61K 007/22

Abstract

A method for inhibiting bacteria in the mouth of a patient which includes placing a particle containing a degradable material and an anti-microbial agent in the mouth of the patient. The exterior of the particle is water-stable. The particles may be coated on dental floss or the bristles of a toothbrush, or incorporated into an oral rinse. Once placed in the mouth, the degradable material degrades to cause release of the anti-microbial agent, resulting in the inhibition of bacteria in the mouth.

Other References

Pekarek et al., "Double walled polymer microspheres for controled drug release", Nature, vol. 367, 20 Jan. 1994, pp. 258 260
Gref et al., "Biodegradable Long Circulating Polymeric Nanospheres", Science, vol. 263, 18 Mar. 1994, pp. 1600 1603
Mathiowitz et al., "Morphology of Polyanhydride Microsphere Delivery Systems", Scanning Micreoscopy, vol. 4, No. 2, 1990, pp. 329 340
Juliano, "Controlled delivery of drugs: an overview and prospectus", Drug Delivery Systems (1980)
Ratner, "Biomedical Applications of Synthetic Polymers", Comprehensive Polymer Science, vol. 7 (1989)
Mathiowitz et al., "Morphology of Polyanhydrine Microsphere Delivery Systems", Scanning Microscopy, 4:329-340 (1990)
Pekarek et al., "Double-walled polymer microspheres for controlled drug release", Letters to Nature, 367:258-260 (Jan., 1994)
Muller et al., "In vitro characterization of poly(methyl-methacrylate) nanoparticles and correlation to their vivo fate", Journal of Controlled Release, 20:237-246 (1992