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US Patent 5616315 - Particles including degradable material and anti-microbial agent

US Patent Issued on April 1, 1997
Estimated Patent Expiration Date: Icon_subject October 13, 2014Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A method for inhibiting bacteria in the mouth of a patient which includes placing a particle containing a degradable material and an anti-microbial agent in the mouth of the patient. The exterior of the particle is water-stable. The particles may be coated on dental floss or the bristles of a toothbrush, or incorporated into an oral rinse. Once placed in the mouth, the degradable material degrades to cause release of the anti-microbial agent, resulting in the inhibition of bacteria in the mouth.

Other References

  • Pekarek et al., "Double walled polymer microspheres for controled drug release", Nature, vol. 367, 20 Jan. 1994, pp. 258 260
  • Gref et al., "Biodegradable Long Circulating Polymeric Nanospheres", Science, vol. 263, 18 Mar. 1994, pp. 1600 1603
  • Mathiowitz et al., "Morphology of Polyanhydride Microsphere Delivery Systems", Scanning Micreoscopy, vol. 4, No. 2, 1990, pp. 329 340
  • Juliano, "Controlled delivery of drugs: an overview and prospectus", Drug Delivery Systems (1980)
  • Ratner, "Biomedical Applications of Synthetic Polymers", Comprehensive Polymer Science, vol. 7 (1989)
  • Mathiowitz et al., "Morphology of Polyanhydrine Microsphere Delivery Systems", Scanning Microscopy, 4:329-340 (1990)
  • Pekarek et al., "Double-walled polymer microspheres for controlled drug release", Letters to Nature, 367:258-260 (Jan., 1994)
  • Muller et al., "In vitro characterization of poly(methyl-methacrylate) nanoparticles and correlation to their vivo fate", Journal of Controlled Release, 20:237-246 (1992

Inventors

Assignee

Application

No. 322926 filed on 10/13/1994

US Classes:

424/54, Ammonia, amine, or derivative thereof (e.g., urea, etc.)424/401, Cosmetic, antiperspirant, dentifrice424/490, Coated (e.g., microcapsules)424/497, Containing solid synthetic polymers424/501Contains solid synthetic resin

Field of Search

424/54, Ammonia, amine, or derivative thereof (e.g., urea, etc.)424/401, Cosmetic, antiperspirant, dentifrice424/490, Coated (e.g., microcapsules)424/497, Containing solid synthetic polymers424/501Contains solid synthetic resin

Examiners

Primary: Geist, Gary
Assistant: Williams, Rosalynd A.

Attorney, Agent or Firm

US Patent References

Re24899, 3523906, 3699979, 3934001, Oral compositions containing germicidally active plastic powders
Issued on: 01/20/1976
Inventor: Watson
3943949, Flavored dental articles
Issued on: 03/16/1976
Inventor: Ashton ,   et al.
3957964, Dentifrice containing encapsulated flavoring
Issued on: 05/18/1976
Inventor: Grimm, III
3959457, Microparticulate material and method of making such material
Issued on: 05/25/1976
Inventor: Speaker ,   et al.
3991766, Controlled release of medicaments using polymers from glycolic acid
Issued on: 11/16/1976
Inventor: Schmitt ,   et al.
4033365, Flavored dental articles
Issued on: 07/05/1977
Inventor: Klepak ,   et al.
4348378, Plaque disclosing dentifrice compositions with semi-solid microcapsules of dye
Issued on: 09/07/1982
Inventor: Kosti
4389330, Microencapsulation process
Issued on: 06/21/1983
Inventor: Tice ,   et al.
4568559, Composite core coated microparticles and process of preparing same
Issued on: 02/04/1986
Inventor: Nuwayser ,   et al.
4622244, Process for preparation of microcapsules
Issued on: 11/11/1986
Inventor: Lapka ,   et al.
4623588, Controlled release composite core coated microparticles
Issued on: 11/18/1986
Inventor: Nuwayser ,   et al.
4685883, Local delivery of chemotherapeutic agents for the treatment of periodontal disease
Issued on: 08/11/1987
Inventor: Jernberg
4780320, Controlled release drug delivery system for the periodontal pocket
Issued on: 10/25/1988
Inventor: Baker
4828955, Microencapsulated particles and process for production thereof
Issued on: 05/09/1989
Inventor: Kasai ,   et al.
4837007, Fluoridating oral cavity
Issued on: 06/06/1989
Inventor: Duckworth ,   et al.
4861627, Preparation of multiwall polymeric microcapsules
Issued on: 08/29/1989
Inventor: Mathiowitz ,   et al.
4867988, Dentifrice containing microencapsulated oxygen
Issued on: 09/19/1989
Inventor: Chernack
4892736, Intra-pocket drug delivery devices for treatment of periodontal diseases
Issued on: 01/09/1990
Inventor: Goodson
4904479, Drug delivery system
Issued on: 02/27/1990
Inventor: Illum
4917892, Encapsulated topical delivery system
Issued on: 04/17/1990
Inventor: Speaker, et al.
4919939, Periodontal disease treatment system
Issued on: 04/24/1990
Inventor: Baker
4959220, Antiseptic-containing alginate impression material
Issued on: 09/25/1990
Inventor: Yamamoto, et al.
4978391, Intraoral medicament delivery and procedure
Issued on: 12/18/1990
Inventor: Jones
4980150, Chlorhexidine complex
Issued on: 12/25/1990
Inventor: Keith
5061106, Toothbrush with slow release of disinfectant and antibacterial agents and method of manufacturing the same
Issued on: 10/29/1991
Inventor: Kent
5098711, Method of treating the oral cavity with dental floss containing chemotherapeutic agents
Issued on: 03/24/1992
Inventor: Hill, et al.
5211939, Method for desensitizing teeth
Issued on: 05/18/1993
Inventor: Turesky, et al.
5219554, Hydrated biodegradable superparamagnetic metal oxides
Issued on: 06/15/1993
Inventor: Groman, et al.
5225282, Biodegradable magnetic microcluster comprising non-magnetic metal or metal oxide particles coated with a functionalized polymer
Issued on: 07/06/1993
Inventor: Chagnon, et al.
5250288, Method for desensitizing teeth
Issued on: 10/05/1993
Inventor: Turesky, et al.
5262166, Resorbable bioactive phosphate containing cements
Issued on: 11/16/1993
Inventor: Liu, et al.
5281265, Resorbable surgical cements
Issued on: 01/25/1994
Inventor: Liu
5382468, Biodegradable magnetic microclusters and methods for making them
Issued on: 01/17/1995
Inventor: Chagnon, et al.
5447725Methods for aiding periodontal tissue regeneration
Issued on: 09/05/1995
Inventor: Damani, et al.

Foreign Patent References

  • 0244118 EP 11/21/1987
  • WO92/20319 WO. 11/21/1992
  • WO93/05680 WO. 04/21/1993
  • WO93/11754 WO. 06/21/1993
  • WO94/08562 WO. 04/21/1994
  • 94/08562 WO. 04/21/1994

International Class

A61K 007/22

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