Compounds useful for treating allergic and inflammatory diseases
Patent 5614540 Issued on March 25, 1997. Estimated Expiration Date: 
May 18, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 18, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3862239 Bisarylamines Patent #: 4795757 InventorAssigneeApplicationNo. 457942 filed on 05/18/1995US Classes:514/362, 1,2,5-thiadiazoles (including hydrogenated)514/363, 1,3,4-thiadiazoles (including hydrogenated)514/364, Oxadiazoles (including hydrogenated)514/381, Tetrazoles (including hydrogenated)514/521, C=O other than as ketone or aldehyde548/127, 1,2,3-thiadiazoles (including hydrogenated)548/128, 1,2,4-thiadiazoles (including hydrogenated)548/131, 1,2,4-oxadiazoles (including hydrogenated)548/134, 1,2,5-thiadiazoles (including hydrogenated)548/136, 1,3,4-thiadiazoles (including hydrogenated)548/143, 1,3,4-oxadiazoles (including hydrogenated)548/252Chalcogen attached indirectly to the tetrazole ring by nonionic bondingExaminersPrimary: Haley, JacquelineAttorney, Agent or FirmForeign Patent References
International ClassesA61K 031/275C07C 255/50 AbstractNovel compounds of Formula (I) ##STR1## where X4 is a substituted cyclohexane or cyclohexane group and the other radicals are defined herein. These compounds inhibit the production of Tumor Necrosis Factor and are useful in the treatment of disease states mediated or exacerbated by TNF production. The compounds of the present invention are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodiesterase IV and are therefore useful in the treatment of disease states in need of mediation or inhibition thereof.Other References
Field of SearchBenzene ring attached indirectly to the cyano group by nonionic bonding (i.e., alicyclic ring between the benzene ring and the cyano group)1,2,3-thiadiazoles (including hydrogenated) 1,2,4-thiadiazoles (including hydrogenated) 1,2,4-oxadiazoles (including hydrogenated) 1,2,5-thiadiazoles (including hydrogenated) 1,3,4-thiadiazoles (including hydrogenated) 1,3,4-oxadiazoles (including hydrogenated) Chalcogen attached indirectly to the tetrazole ring by nonionic bonding C=O other than as ketone or aldehyde 1,2,5-thiadiazoles (including hydrogenated) 1,3,4-thiadiazoles (including hydrogenated) Oxadiazoles (including hydrogenated) Tetrazoles (including hydrogenated) |
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