N,N-di(aryl) cyclic urea derivatives as anti-coagulants
Patent 5612363 Issued on March 18, 1997. Estimated Expiration Date: 
June 2, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 2, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesHeteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors Patent #: 5332822 InventorsAssigneeApplicationNo. 458598 filed on 06/02/1995US Classes:514/392, Divalent chalcogen or acyclic nitrogen double bonded at 2-position, or tautomeric equivalent548/322.5, Having -C(=X)-, wherein X is chalcogen, bonded directly to the diazole ring548/323.1, Acyclic nitrogen bonded directly to the -C(=X)- group548/323.5, Chalcogen attached indirectly to the diazole ring by acyclic nonionic bonding548/324.1, The chalcogen, X, is in a -C(=X)- group548/324.5Nitrogen attached indirectly to the diazole ring by acyclic nonionic bondingExaminersPrimary: Morris, Patricia L.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/415C07D 233/32 AbstractN,N-di(aryl) cyclic urea derivatives, such as the compounds of the following formula: ##STR1## wherein R1 is --C(NH)NH2, --C(NH)N(H)OR11, --C(NH)N(H)C(O)R9, or --C(NH)N(H)C(O)OR11 ;R2 and R3 are independently hydrogen, halo, lower alkyl, lower haloalkyl, aryl, --OR11, --C(O)OR11, --C(O)N(R11)R12, --N(R11)R12, --N(H)C(O)R11, or --N(H)S(O)2 R11 ;R4 is halo, lower haloalkyl, imidazolyl, --C(NH)NH2, --C(NH)NHOR11, --C(NH)N(H)C(O)R9, --C(NH)N(H)C(O)OR11, --OR11, --C(O)R13, --(CH2)n C(O)OR11 (where n is 0 to 6), --C(O)N(R11)R12, or --N(R11)R12 ;R7 and R8 are independently hydrogen, lower alkyl, lower haloalkyl, 4-pyridinyl, --C(O)OR11, --C(O)N(R11)R12, or aryl (optionally substituted by one or more substituents selected from the group consisting of halo, hydroxy, lower alkyl, lower haloalkyl, lower alkoxy and --N(R11 R12);R11 and R12 are independently hydrogen, lower alkyl, aryl or lower aralkyl; orR13 is pyrrolidinyl, 4-morpholinyl, piperazinyl, N-methylpiperazinyl, or piperidinyl; or apharmaceutically acceptable salt thereof, are disclosed herein as being inhibitors of factor Xa and thereby being useful as anticoagulants.Other References
Field of SearchHaving -C(=X)-, wherein X is chalcogen, bonded directly to the diazole ringAcyclic nitrogen bonded directly to the -C(=X)- group Chalcogen attached indirectly to the diazole ring by acyclic nonionic bonding The chalcogen, X, is in a -C(=X)- group Nitrogen attached indirectly to the diazole ring by acyclic nonionic bonding Divalent chalcogen or acyclic nitrogen double bonded at 2-position, or tautomeric equivalent |
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