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US Patent 5610283 - Opiate derivatives and protein and polypeptide opiate derivative conjugates and labels
US Patent Issued on March 11, 1997
Estimated Patent Expiration Date:
February 15, 2015Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
February 15, 2015Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractThe present invention is directed to novel opiate derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the opiates and opiate metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.Other References
| InventorAssigneeApplicationNo. 389969 filed on 02/15/1995US Classes:530/404, Sulfur containing reactant435/188, Stablizing an enzyme by forming a mixture, an adduct or a composition, or formation of an adduct or enzyme conjugate435/961, INCLUDING A STEP OF FORMING, RELEASING, OR EXPOSING THE ANTIGEN OR FORMING THE HAPTEN-IMMUNOGENIC CARRIER COMPLEX OR THE ANTIGEN, PER SE436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN436/816, Alkaloids, amphetamines, and barbiturates530/408, Sulfur containing reactant536/17.4, Nitrogen in aglycone moiety546/44One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)Field of Search530/404, Sulfur containing reactant530/408, Sulfur containing reactant435/964, INCLUDING ENZYME-LIGAND CONJUGATE PRODUCTION (E.G., REDUCING RATE OF NONPRODUCTIVE LINKAGE, ETC.)435/961, INCLUDING A STEP OF FORMING, RELEASING, OR EXPOSING THE ANTIGEN OR FORMING THE HAPTEN-IMMUNOGENIC CARRIER COMPLEX OR THE ANTIGEN, PER SE435/188, Stablizing an enzyme by forming a mixture, an adduct or a composition, or formation of an adduct or enzyme conjugate436/501, BIOSPECIFIC LIGAND BINDING ASSAY436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN436/544, Producing labeled antigens436/816, Alkaloids, amphetamines, and barbiturates436/822, IDENTIFIED HAPTEN436/824, IMMUNOLOGICAL SEPARATION TECHNIQUES436/901, DRUGS OF ABUSE (E.G., NARCOTICS, AMPHETAMINE, ETC.)546/64, Three or more ring hetero atoms in the tetracyclo ring system536/17.4Nitrogen in aglycone moietyExaminersPrimary: Kim, Harry C.Attorney, Agent or FirmUS Patent References3852157, 3884898, 4231999, Method in assaying methods involving biospecific affinity reactions and reagent for use in said methodIssued on: 11/04/1980 Inventor: Carisson , et al.4232119, Reagent for use in immunochemical assay methods Issued on: 11/04/1980 Inventor: Carlsson , et al.4695624, Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency Issued on: 09/22/1987 Inventor: Marburg , et al.4939264Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies Issued on: 07/03/1990 Inventor: Heiman, et al. Foreign Patent References
International ClassesC07K 017/02C07D 489/02 C07H 017/00 A61K 039/385 |
