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US Patent 5610283 - Opiate derivatives and protein and polypeptide opiate derivative conjugates and labels

US Patent Issued on March 11, 1997
Estimated Patent Expiration Date: Icon_subject February 15, 2015Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The present invention is directed to novel opiate derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the opiates and opiate metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.

Other References

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  • Colbert et al (1988) J. Immunoassay 9(3 & 4): 367-383
  • Blair et al (1983) J. Immunol. Methods 59:129-143
  • Jung et al (1981) Biochem. Biophys. Res. Commun. 101(2): 599-604
  • Cone, Edward J. et al., Forensic Drug Testing for Opiates: IV. Analytical, Sensitivity, Specificity and Accuracy of Commercial Urine Opiate Immunoassays, J. Anal. Tox. 16:72-78 (1992)
  • Cone, Edward J. et al., Forensic Drug Testing for Opiates:I. Detection of 6-Acetylmorphine in Urine as an Indicator of Recent Heroin Exposure; Drug and Assay Considerations and Detection Times, J. Anal. Tox. 15:1-7 (1991)
  • Kaiser, Carl et al., Sigma Receptor Ligands: Function and Activity, Neurotransmissions: 7: No. 1 1-8 (1991)
  • McKnight, Alexander and Rees, David C. Neurotransmissions: 7: No. 2 1-8 (1991)
  • Ram, Vishnu J. and Neumeyer, John L., Aporphines, 42. Synthesis of (R)-(-D-11-Hydroxaporphines from Morphine, J. Org. Chem. 47:4372-74 (1982)
  • Krafft, Grant A., et al., Photoactivable Flurophones 3. Synthesis and Photoactivation of Flurogenic Difunctionalized Fluroescerns, J. Am. Chem. Soc. 110:301-03 (1989)
  • Rice, Kenner, C. and May Everette L., Procedural Refinements in the N-Demethylation of Morphine and Codeine Using Phenyl Chloroformate and Hydrazine, J. Heterocyclic Chem. 14:665-66 (1977)
  • Rice, Kenner, C. and Jacobson, Arthur E., Preparation and Analgesic Activity of 3,6-Diacetyl-normorphine and 6-Acetylnormorphine, J. Med. Chem. 18:1033-35 (1975)
  • Weijlard, John and Erickson, A. E., N-Allylnormorphine JACS 64:869-70 (1942)
  • Brine, George A. et al., the N-Demethylation of Morphone and Codeine Using Methyl Chloroformate, Organic Preparations and Procedures, Int. 8:103-106 (1975)
  • Kosterlitz, H. W. et al., the assay of the agonist activities of N-methyl and N-nor-homologies of morphine derivatives by the guinea pig ileum method, J. Pharm. Pharmac. 28:325 (1976)
  • Rice, Kenner C., An improved Procedure for the N-Demethylation of 6,7-Benzo morphines, Morphine, and Codeine, J. Org. Chem. 40:1850-51 (1975)
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Inventor

Assignee

Application

No. 389969 filed on 02/15/1995

US Classes:

530/404, Sulfur containing reactant435/188, Stablizing an enzyme by forming a mixture, an adduct or a composition, or formation of an adduct or enzyme conjugate435/961, INCLUDING A STEP OF FORMING, RELEASING, OR EXPOSING THE ANTIGEN OR FORMING THE HAPTEN-IMMUNOGENIC CARRIER COMPLEX OR THE ANTIGEN, PER SE436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN436/816, Alkaloids, amphetamines, and barbiturates530/408, Sulfur containing reactant536/17.4, Nitrogen in aglycone moiety546/44One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)

Field of Search

530/404, Sulfur containing reactant530/408, Sulfur containing reactant435/964, INCLUDING ENZYME-LIGAND CONJUGATE PRODUCTION (E.G., REDUCING RATE OF NONPRODUCTIVE LINKAGE, ETC.)435/961, INCLUDING A STEP OF FORMING, RELEASING, OR EXPOSING THE ANTIGEN OR FORMING THE HAPTEN-IMMUNOGENIC CARRIER COMPLEX OR THE ANTIGEN, PER SE435/188, Stablizing an enzyme by forming a mixture, an adduct or a composition, or formation of an adduct or enzyme conjugate436/501, BIOSPECIFIC LIGAND BINDING ASSAY436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN436/544, Producing labeled antigens436/816, Alkaloids, amphetamines, and barbiturates436/822, IDENTIFIED HAPTEN436/824, IMMUNOLOGICAL SEPARATION TECHNIQUES436/901, DRUGS OF ABUSE (E.G., NARCOTICS, AMPHETAMINE, ETC.)546/64, Three or more ring hetero atoms in the tetracyclo ring system536/17.4Nitrogen in aglycone moiety

Examiners

Primary: Kim, Harry C.

Attorney, Agent or Firm

US Patent References

3852157, 3884898, 4231999, Method in assaying methods involving biospecific affinity reactions and reagent for use in said method
Issued on: 11/04/1980
Inventor: Carisson ,   et al.
4232119, Reagent for use in immunochemical assay methods
Issued on: 11/04/1980
Inventor: Carlsson ,   et al.
4695624, Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
Issued on: 09/22/1987
Inventor: Marburg ,   et al.
4939264Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies
Issued on: 07/03/1990
Inventor: Heiman, et al.

Foreign Patent References

  • 0254120 EP 07/21/1984
  • 9218866 WO. 10/21/1992

International Classes

C07K 017/02
C07D 489/02
C07H 017/00
A61K 039/385

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