Opiate derivatives and protein and polypeptide opiate derivative conjugates and labels
Patent 5610283 Issued on March 11, 1997. Estimated Expiration Date: 
February 15, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 15, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3852157 3884898 Method in assaying methods involving biospecific affinity reactions and reagent for use in said method Reagent for use in immunochemical assay methods Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies Patent #: 4939264 InventorAssigneeApplicationNo. 389969 filed on 02/15/1995US Classes:530/404, Sulfur containing reactant435/188, Stablizing an enzyme by forming a mixture, an adduct or a composition, or formation of an adduct or enzyme conjugate435/961, INCLUDING A STEP OF FORMING, RELEASING, OR EXPOSING THE ANTIGEN OR FORMING THE HAPTEN-IMMUNOGENIC CARRIER COMPLEX OR THE ANTIGEN, PER SE436/543, INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN436/816, Alkaloids, amphetamines, and barbiturates530/408, Sulfur containing reactant536/17.4, Nitrogen in aglycone moiety546/44One of the five cyclos is five-membered and includes ring chalcogen (e.g., codeine, morphine, etc.)ExaminersPrimary: Kim, Harry C.Attorney, Agent or FirmForeign Patent References
International ClassesC07K 017/02C07D 489/02 C07H 017/00 A61K 039/385 AbstractThe present invention is directed to novel opiate derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to the opiates and opiate metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.Other References
Field of SearchSulfur containing reactantSulfur containing reactant INCLUDING ENZYME-LIGAND CONJUGATE PRODUCTION (E.G., REDUCING RATE OF NONPRODUCTIVE LINKAGE, ETC.) INCLUDING A STEP OF FORMING, RELEASING, OR EXPOSING THE ANTIGEN OR FORMING THE HAPTEN-IMMUNOGENIC CARRIER COMPLEX OR THE ANTIGEN, PER SE Stablizing an enzyme by forming a mixture, an adduct or a composition, or formation of an adduct or enzyme conjugate BIOSPECIFIC LIGAND BINDING ASSAY INVOLVING PRODUCING OR TREATING ANTIGEN OR HAPTEN Producing labeled antigens Alkaloids, amphetamines, and barbiturates IDENTIFIED HAPTEN IMMUNOLOGICAL SEPARATION TECHNIQUES DRUGS OF ABUSE (E.G., NARCOTICS, AMPHETAMINE, ETC.) Three or more ring hetero atoms in the tetracyclo ring system Nitrogen in aglycone moiety |
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