DNA diagnostic based on mass spectrometry
Patent 5605798 Issued on February 25, 1997. Estimated Expiration Date: 
March 17, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 17, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesProcess for amplifying, detecting, and/or-cloning nucleic acid sequences Determining DNA sequences by mass spectrometry Instrument and method for the laser desorption of ions in mass spectrometry Genomic sequencing method Laser ablation/ionizaton and mass spectrometric analysis of massive polymers Multiplex analysis of DNA Instrument and method for the sequencing of genome Patent #: 5288644 InventorAssigneeApplicationNo. 406199 filed on 03/17/1995US Classes:435/6, Involving nucleic acid435/91.1, Polynucleotide (e.g., nucleic acid, oligonucleotide, etc.)435/91.2, Acellular exponential or geometric amplification (e.g., PCR, etc.)536/25.3, Synthesis of polynucleotides or oligonucleotides536/25.4Separation or purification of polynucleotides or oligonucleotidesExaminersPrimary: Jones, W. GaryAssistant: Tran, Pablo N. Attorney, Agent or FirmForeign Patent References
International ClassesC07H 021/04C12P 019/34 C12Q 001/68 AbstractThe invention provides fast and highly accurate mass spectrometer based processes for detecting a particular nucleic acid sequence in a biological sample. Depending on the sequence to be detected, the processes can be used, for example, to diagnose (e.g. prenatally or postnatally) a genetic disease or chromosomal abnormality; a predisposition to a disease or condition (e.g. obesity, artherosclerosis, cancer), or infection by a pathogenic organism (e.g. virus, bacteria, parasite or fungus).Other References
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