Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
Patent 5603351 Issued on February 18, 1997. Estimated Expiration Date: 
June 7, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 7, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3650296 3901731 Valve with flexible sheet member Particle analysis system Method of manufacturing radiation detector window structure Acoustic wave microsensors for measuring fluid flow Plate-mode ultrasonic sensor Micromechanical thermoelectric sensor element Fluid delivery system Liquid supplying device for use in physical and chemical apparatus Patent #: 5447691 Inventors
AssigneeApplicationNo. 483331 filed on 06/07/1995US Classes:137/597, Multiple inlet with multiple outlet204/269, With feeding and/or withdrawal means204/600, Electrophoretic or electro-osmotic apparatus204/601Capillary electrophoresis typeExaminersPrimary: Valentine, Donald R.Attorney, Agent or FirmInternational ClassesF17D 001/14F17D 001/20 C25B 015/08 AbstractA system and method for accomplishing a plurality of combinatorial processes in parallel comprising a microelectronic and fluidic array (device array) having micron-sized reservoirs, connecting microchannels and reaction cells etched into a substrate. The device array is supported by a station which serves to interface and perform electro-optic measurements of material in the reaction cells of the device array. The device array incorporates a modular configuration with three distinct layers or plates. The device array comprises a top feedthru plate, a center distribution plate and a bottom cell plate. The three plates are stacked vertically and coupled together to form a liquid-tight seal. Reservoirs, microchannels and reactions cells are controllably etched onto the plates using traditional semiconductor fabrication techniques. The top feedthru plate serves as a cover for the device array and contains apertures selectively positioned above the reservoirs located in the center distribution plate. The center distribution plate comprises a plurality of micron sized reservoirs, microchannels, reservoir feeds, cell feeds and overflow feeds for the distribution of reagent fluids to the reaction cells located in the bottom cell plate. The detachable bottom cell plate serves as a microlaboratory tray of reaction cells. Once the proper reagents or other materials are introduced into the reaction cells, the bottom cell plate is decoupled from the device array and removed for incubation or analysis.Other References
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