Non-human mammal having a graft and methods of delivering protein to myocardial tissue
Patent 5602301 Issued on February 11, 1997. Estimated Expiration Date: November 16, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
800/8, NONHUMAN ANIMAL424/93.21, Eukaryotic cell424/93.7, Animal or plant cell435/69.1Recombinant DNA technique included in method of making a protein or polypeptide
Described are preferred myocardial grafts of skeletal myoblasts or cardiomyocytes, and cellular compositions and methods useful in obtaining the grafts. The myocardial grafts are stable and can be used, for example, to deliver recombinant proteins directly to the heart.
Other References
Acsadi et al (1991) New Biologist 3, 71-81
Jacobson et al. (1983) Can. J. Physiol. Pharmacol. 61, 1312-1316
Steinhelper, M. E., Cochrane, K. L. and Field, L. J., "Hypotension In Transgenic Mice Expressing Atrial Natriuretic Factor Fusion Genes", Hypertension, vol. 16, No. 3, pp. 301-307 (1990)
Development, vol. 110, issued 1990, Y. Lallemand et al., "An in situ Asessment of the Routes and Extents of Colonisation of the Mouse Embryonic Stem Cells and their Descendants", pp. 1241-1248, see entire document
DNA, vol. 5, No. 5, issued 1986, R. J. MacDonald et al., "Transgenic Progeny Inherit Tissue-Specific Expression of Rat Elastase I Genes", pp. 393-401, see entire document
Science, vol. 254, issued 1991, Dhawan et al., "Systemic Delivery of Human Growth Hormone by Injection of Genetically Engineered Myoblasts", pp. 1509-1512
Brunner, A. M. et al, "Site-Directed Mutagenesis Of Cysteine Residues In The Pro Region Of The Transforming Growth Factor beta 1 Precursor. Expression And Characterization Of Mutant Proteins," J. Biol. Chem., 264(23):13660-13664, 1989
Delcarpio, J. B., Lanson, N. A., Jr., Field, L. J. and Claycomb, W. C., "Morphological Characterization Of Cardiomyocytes Isolated From A Transplantable Cardiac Tumor Derived From Transgenic Mouse Atria (AT-1 cells)," Circ. Rsrch., 69:1591-1600, 1991
Field, L. J., "Atrial Natriuretic Factor-SV40 T Antigen Transgenes Produce Tumors And Cardiac Arrhythmias In Mice," Science, 239:1029-1033, 1988
Gussoni, E., Pavlath, G. K., Lanctot, A. M., Sharma, K. R., Miller, R. G., Steinman, L. and Blau, H. M., "Normal Dystrophin Transcripts Detected In Duchenne Muscular Dystrophy Patients After Myoblast Transplantation," Nature, 356:435-438, 1992
Janse, M. J., Cinca, J., Morena, H., Fiolet, J. W., Kleber, A. G., deVries, G. P., Becker, A. E. and Durrer, D., "The Border Zone In Myocardial Ischemia. An Electrophysiological, Metabolic And Histochemical Correlation In The Pig Heart," Circulation Research, 44:576-588, 1979
Jiao, S., Gurevich, V. and Wolff, J. A., "Long-Term Correction Of Rat Model Of Parkinson's Disease By Gene Therapy", Nature, vol. 362, pp. 450-453 (1993)
Katz, E., Steinhelper, M. E., Daud, A., Delcarpio, J. B., Claycomb, W. C. and Field, L. J. "Cardiomyocyte Proliferation In Mice Expressing -Cardiac Myosin Heavy Chain-SV40 T-Antigen Transgenes," Amer. J. Phys., 262 (Heart and Circulatory Physiology 31): H1867-1876, 1992
Koh, G. Y., Klug, M. G., Soonpaa, M. H., and Field, L. J., "Differentiation And Long-Term Survival of C2C12 Myoblst Grafts In Heart," J. Clin. Invest., vol. 92, Sep. 1993
Koh, G. Y., Soonpaa, M. H., Klug, M. G. and Field, L. J., "Long-Term Survival Of AT-1 Cardiomyocyte Grafts In Syngeneic Myocardium," Amer. Physiol. Soc., pp. H1727-H1733 (1993)
Loewy, A. D., Bridgman, P. C. and Mettenleiter, T. C., "ଲ-Galactosidase Expressing Recombinant Pseudorabies Virus For Light And Electron Microscopic Study Of Transneuronally Labeled CNS Neurons," Brain Research, 555:346, 1991
Nadal-Ginard, B., "Commitment, Fusion, And Biochemical Differentiation Of A Myogenic Cell Line In The Absence Of DNA Synthesis," Cell, 15:885-864, 1978
Rockman, H. A., Ross, R. A., Harris, A. N., Knowlton, K. U., Steinhelper, M. E., Field, L. J., Ross, J., Jr. and Chien, K. R., "Segregation Of Atrial-Specific And Inducible Expression Of An ANF Transgene In An in vivo Murine Model Of Cardiac Hypertrophy," Proc. Natl. Acad. Sci., USA, 88:8277-8281, 1991
Samuel, S. K. et al, "Autocrine Induction Of Tumor Protease Production And Invasion By A Metallothionein-Regulated TGF-beta 1" (Ser223,225), Embo Journal [JC:emb], 11(4):1599-1605, 1992
Spear, J. F., Michelson, E. L., and More, E. N., "Cellular Electrophysiologic Characteristics Of Chronically Infarcted Myocardium In Dogs Susceptible To Sustained Ventricular Tachyarrhythmias," J. of the Amer. College of Cardiology, 4:1099-1110, 1983
Steinhelper, M. E., Cochrane, K. L. and Field, L. J., "Hypotension In Transgenic Mice Expressing Atrial Natriuretic Factor Fusion Genes," Hypertension, 16:301-307, 1990
Steinhelper, M. E. and Field, L. J., "Cardiac Tumors And Dysrhythmias In Transgenic Mice," Toxicologic Pathology, 18:464-469, 1990
Steinhelper, M. E., Lanson, N., Dresdner, K., Delcarpio, J. B., Wit, A., Claycomb, W. C. and Field, L. J., "Proliferation In Vivo And In Culture Of Differentiated Adult Atrial Cardiomyocytes From Transgenic Mice", Amer. J. Phys., 259 (Heart and Circulatory Physiology 28): H1826-H1834, 1990
Thompson, L., "Fetal Transplants Show Promise", Science, 257:868-870, 1992
Yaffe, D., and O. Saxel, "Serial Passaging And Differentiation Of Myogenic Cells Isolated From Dystrophic Mouse Muscle," Nature, 270:725-727, 197
November 16, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
