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Treatment of nicotine craving and/or smoking withdrawal symptoms

Patent 5599554 Issued on February 4, 1997. Estimated Expiration Date: Icon_subject March 19, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Transcutaneous application of nicotine
Patent #: 4597961
Issued on: 07/01/1986
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Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics
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Bioadhesive extruded film for intra-oral drug delivery and process
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Method for treatment of nicotine craving
Patent #: 4778677
Issued on: 10/18/1988
Inventor: Ebbesen

Tobacco product
Patent #: 4806356
Issued on: 02/21/1989
Inventor: Shaw

Compositions and methods of manufacture of compressed powder medicaments
Patent #: 4863737
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Inventor: Stanley ,   et al.

Gel bases for pharmaceutical compositions
Patent #: 4883660
Issued on: 11/28/1989
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Mucoadhesive buccal dosage forms
Patent #: 4900552
Issued on: 02/13/1990
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Inventor

Assignee

Application

No. 619860 filed on 03/19/1996

US Classes:

424/448, Pressure sensitive adhesive means424/434, Mucosal (e.g., nasal, etc.)424/435, Mouth424/449, Transdermal or percutaneous514/813Tobacco

Examiners

Primary: Phelan, D. Gabrielle

Attorney, Agent or Firm

Foreign Patent References

  • 0192950 EP 09/13/1986
  • 0563507 EP 10/13/1993
  • 91/03998 WO 04/13/1991

International Class

A61F 013/02

Abstract

The subject invention encompasses a transdermally or transmucosally administrable composition for the treatment or nicotine craving or smoking withdrawal symptoms comprising nicotine and caffeine or caffeine equivalent.

Other References

  • Cohen, C., et al., "Caffeine Antagonizes EEG Effects of Tobacco Withdrawal", Pharmacology Biochemistry and Behavior, vol. 47, No. 4, pp. 919-926 (Apr., 1994)
  • Tariq, M., et al., "Effect of Nicotine and Caffeine Pretreatment on the Gastric Mucosal Damage Induced by Aspirin, Phenylbutazone, and Reserpine in Rats", Toxicology and Applied Pharmacology, vol. 79, No. 2, pp. 268-273 (Jun. 30, 1985)
  • Wilson, Steven P., "Pertussis Toxin Enhances Proenkephalin Synthesis in Bovine Chromaffin Cells", Journal of Neurochemistry, vol. 61, No. 5, pp. 1901-1906 (Nov., 1993
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