Patent 5593838 Issued on January 14, 1997. Estimated Expiration Date: May 31, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
435/6, Involving nucleic acid204/450, Electrophoresis or electro-osmosis processes and electrolyte compositions therefor when not provided for elsewhere435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid435/288.5Including means for fluid passage between compartments (e.g., between wells, etc.)
A system for processing a plurality of tests or syntheses in parallel comprising a sample channel for moving samples into a microlaboratory array of a plurality of wells connected by one or more channels for the testing or synthesis of samples, a station for housing the array and an optical system comprising at least one light source and at least one light detector for measuring the samples in the array, and a means of electrically connecting said array to an apparatus capable of monitoring and controlling the flow of fluids into the array. Samples are loaded from a common loading channel into the array, processed in the wells and measurements taken by the optical system. The array can process many samples, or synthesize many compounds in parallel, reducing the time required for such processes.
Other References
Search Report for WO 93/22055, Micro-Fabricated Analytical Device for Fluid, Cell-Containing Sample and has Cell Membrane Piercing Protrusions in Flow Path with Restricted Region Allowing Passage of Intracellular Molecules Only
Search Report for WO 93/22053, Micro-Fabricated Analyte Detection Appts. and Has Substrate with Inlet Port Connected to Detection Region Having Binding Moiety for Specifically Binding Analyte
Dasgupta, et al., Electroosmosis: A Reliable Fluid Propulsion System for Flow Injection Analysis, Anal. Chem. 1994, 66:1792-1798, 1994
Richeter, et al., A Micromachined ElectroHydrodynamic (EHD) Pump, Sensors and Actuators A, 29:159-168, 1992
Bart, et al., Microfabricated Electrohydrodynamic Pumps, Sensors and Actuators, A21-A23:193-197, 1990
Melcher, Traveling-Wave Induced Electroconvection, The Physics of Fluids, 9:1548-1555, 1966
Pickard, Ion Drag Pumping. I. Theory, J. Applied Physics 34:246-250, 1963
Pickard, Ion Drag Pumping II. Experiment. J. Applied Physics, 34:251-258, 1963
Stuetzer, Ion Drag Pumps, J. Applied Physics, 31:136-146, 1960
Tracey, et al., Microfabricated Microhaemorheometer, pp. 82-84, 1991
Jacobson, et al., Effects of Injection Schemes and Column Geometry on the Performance of Microchip Electrophoresis Devices, Anal. chem. 1994, 66:1107-1113
Jacobson, et al., High-Speed Separatioins on a Microchip, anal. Chem. 1994, 66:1114-1118
Fan, et al., Micromachining of Capillary Electrophoresis Injectors and Separators on Glass Chips and Evaluation of Flow at Capillary Intersections, Anal. Chem., 1994, 6:177-184
Megregany, Microelectromechanical Systems, Circuits and Devices, Jul. 1993
Harrison, et al., Micromachining a Miniaturized Capillary Electrophoresis-Based Chemical Analysis System on a Chip, Science, vol. 261, Aug. 13, 1993
Harrison, et al., Capillary Electrophoresis and Sample Injection Systems Integrated on a Planar Glass Chip, Anal. Chem. 1992, 64:1926-1932
Fisher, Microchips for Drug Compounds, New York times, Mar. 3, 1991
Fodor, ete al., Light-Directed, Spatially Addressable Parallel Chemical Synthesis, Research Article, Science, vol. 251, Feb. 15, 191, pp. 767-773
The Silver Shotguns, The Economist, Dec. 14-20, 1991
Howe, et al., Silicon Micromechanics; Sensors and Actuators on a Chip, IEEE Spectrum, Jul. 1990
Wenzel, et al., A Multisensor Employng an Ultrasonic Lamb-Wave Oscillator, IEEE Transactions on Electron Devices, vol. 35, No. 5, Jun. 1988
Angell, et al., Silicon Micromechanical Devices, Scientific American 248:44-55, 1983
Petersen, Silicon as a Mechanical Material, Proceedings of the IEEE, vol. 79, No. 5, May 1982
Official Gazette entry for Murphy et al., Automated Capillary Scanning System, U.S. Pat. No. 5,009,503, Apr. 21, 199