Butylene oxide-ethylene oxide block copolymer surfactants as stabilizer coatings for nanoparticle compositions
Patent 5587143 Issued on December 24, 1996. Estimated Expiration Date: 
June 28, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 28, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesInspection device and method for cylindrical work pieces Surface modified drug nanoparticles X-ray contrast compositions useful in medical imaging Oral, cutaneous and intravaginal pharmaceutical compositions in the form of foam Shampoo compositions Patent #: 5393519 InventorApplicationNo. 267082 filed on 06/28/1994US Classes:424/9.1, IN VIVO DIAGNOSIS OR IN VIVO TESTING424/9.45, Halogenated benzene ring containing424/9.455Carbonyl of a carboxylic acid or salt thereof attached directly to the benzene ringExaminersPrimary: Kulkosky, Peter F.Attorney, Agent or FirmInternational ClassesA61K 049/00A61K 049/04 AbstractThis invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a nonionic polymeric surfactant as a surface modifier adsorbed on the surface thereof, the surfactant being a block copolymer of ethylene oxide and butylene oxide and a method of making such nanoparticles. The compositions exhibit reduced macrophage uptake and improved toxicological profiles and facilitate particle size reduction such that milling time can be reduced and/or sterile filtration of the nanoparticles can be accomplished.Other References
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