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Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof

Patent 5578292 Issued on November 26, 1996. Estimated Expiration Date: Icon_subject January 30, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Ultrasonic image enhancement
Patent #: 4276885
Issued on: 07/07/1981
Inventor: Tickner ,   et al.

Carrier liquid solutions for the production of gas microbubbles, preparation thereof, and use thereof as contrast medium for ultrasonic diagnostics
Patent #: 4466442
Issued on: 08/21/1984
Inventor: Hilmann ,   et al.

Contrast agents for ultrasonic imaging
Patent #: 4718433
Issued on: 01/12/1988
Inventor: Feinstein

Porous inorganic ultrasound contrast agents
Patent #: 5147631
Issued on: 09/15/1992
Inventor: Glajch, et al.

Methods for selecting and using gases as ultrasound contrast media Patent #: 5393524
Issued on: 02/28/1995
Inventor: Quay

Inventors

Assignee

Application

No. 380588 filed on 01/30/1995

US Classes:

424/9.51, Liposome containing424/9.5, Ultrasound contrast agent424/9.52, Stable gas bubbles containing or intentional solubilized gas containing424/673, Elemental fluorine or fluorine compound514/744, Unsaturated aliphatic compound514/746, Plural halogenated hydrocarbon compounds514/752, Alkyne514/754, Plural benzene rings514/757Two or more halogenated hydrocarbons

Examiners

Primary: Kumar, Shailendra

Attorney, Agent or Firm

Foreign Patent References

  • 0131540 EP. 01/25/1985
  • 327490 EP. 02/25/1989
  • 0324938 EP. 07/25/1989
  • 0458079A2 EP. 04/25/1991
  • 0458745A1 EP. 11/25/1991
  • 0458745 EP. 11/25/1991
  • WO91/12823 WO. 09/25/1991
  • WO91/15244 WO. 10/25/1991
  • WO92/05806 WO. 04/25/1992

International Class

A61K 049/00

Foreign Application Priority Data

1992-01-23 EP

Abstract

One can impart outstanding resistance against collapse under pressure to gas-filled microvesicle used as contrast agents in ultrasonic echography by using as fillers gases whose solubility in water, expressed in liter of gas by liter of water under standard conditions, divided by the square root of the molecular weight does not exceed 0.003.

Other References

  • P. S. Epstein et al. "On the stability of gas bubbles in liquid-gas solutions" Jour of Chemical Physics, Nov. 1950, vol. 18 No. 1
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