U.S. patents available from 1976 to present.
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Method of treating memory disorders using R-enantiomers of N-propargyl-aminoindan compounds

Patent 5576353 Issued on November 19, 1996. Estimated Expiration Date: Icon_subject June 2, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3201470

3253037

3513244

Pharmaceutical compositions containing levodopa methyl ester, preparation and therapeutic applications thereof
Patent #: 4826875
Issued on: 05/02/1989
Inventor: Chiesi

Propargyl amino compounds Patent #: 5196583
Issued on: 03/23/1993
Inventor: Yamada, et al.

Inventors

Assignee

Application

No. 459402 filed on 06/02/1995

US Classes:

514/647, Amino nitrogen and a ring bonded directly to the same ring and any other amino nitrogen in the compound is bonded directly to one of the rings514/567, Benzene ring nonionically bonded514/614, N-N containing (e.g., aminimine, hydrazine, etc.)564/308Polycyclo ring system

Examiners

Primary: Burn, Brian M.

Attorney, Agent or Firm

Foreign Patent References

  • 1003686 GB. 09/12/1965

International Class

A61K 031/135

Foreign Application Priority Data

1990-01-03 IL

Abstract

R(+)-N-propargyl-1-aminoindan, its preparation and use and pharmaceutical compositions containing it. The novel compound was found to be useful for the treatment of human patients for Parkinson's disease, memory disorders, dementia of the Alzheimer type (DAT), depression and the hyperactive syndrome.

Other References

  • Finberg and Youdim, British J. Pharmac. (Jun. 1985) 85(2):541-546;
  • Kabins and Gershon, Demetia (1990) 1:323-348;
  • The Merck Index (Tenth ed. 1983) pp. 149, 248-249;
  • The Parkinson Study Group, New England J. Med. (1989) 321(20):1364-1371;
  • The Parkinson Study Group, New England J. Med. (Jan. 21, 1993) 328(3):176-183;
  • Riederer and Youdim, J. Neurochem. (1986) 46(5):1359-1365;
  • Tekes, et al., Pol. J. Pharmacol. Pharm. (1988) 40:653-658;
  • Youdim, et al., in Handbook of Experimental Pharmacology vol. 90/I (1988) Chapter 3, Trendelenburg and Weiner, ed
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