U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Drug flux enhancer-tolerant pressure sensitive adhesive composition

Patent 5573778 Issued on November 12, 1996. Estimated Expiration Date: Icon_subject March 17, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3786116

3832423

3842146

3862077

3879494

3928255

Chemically joined phase separated thermoplastic graft copolymers
Patent #: 3989768
Issued on: 11/02/1976
Inventor: Milkovich ,   et al.

Chemically joined, phase separated self-cured hydrophilic thermoplastic graft copolymers and their preparation
Patent #: 4085168
Issued on: 04/18/1978
Inventor: Milkovich, et al.

Acrylic hot melt pressure sensitive adhesive coated sheet material
Patent #: 4551388
Issued on: 11/05/1985
Inventor: Schlademan

Acrylate copolymer pressure-sensitive adhesive composition and sheet materials coated therewith
Patent #: 4554324
Issued on: 11/19/1985
Inventor: Husman ,   et al.

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Inventors

Application

No. 405872 filed on 03/17/1995

US Classes:

424/448, Pressure sensitive adhesive means424/449Transdermal or percutaneous

Examiners

Primary: Phelan, D. Gabrielle

Attorney, Agent or Firm

International Class

A61F 013/02

Abstract

A drug flux enhancer-tolerant pressure sensitive adhesive composition is provided comprised of a mixture of (1) a percutaneous penetration enhancer to increase permeability of skin to transdermally administered pharmacologically active agents and (2) a macromer reinforced base polymer, said base polymer comprising a phase separated graft copolymer composition comprised of copolymerized monomers A and B to form a backbone polymer having polymeric moieties grafted thereto, wherein monomer A is a monomeric acrylic or methacrylic ester of a non-tertiary alcohol having from 1 to 14 carbon atoms, with the average number of carbon atoms being in the range of about 4 to 12, and a monomer B is a polar monomer which is copolymerizable with monomer A.

Other References

  • Pfister, William R. et al., Permeation Enhancers Compatible with Transdermal Drug Delivery Systems Part 1: Selection and Formulation Considerations, Pharmaceutical Technology, pp. 132-140, Sep. 1990
  • Pfister, William R. et al., Permeation Enhancers Compatible with Transdermal Drug Delivery Systems Part II: System Design Considerations, Pharmaceutical Technology, Oct. 199
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