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Fully integrated miniaturized planar liquid sample handling and analysis device

Patent 5571410 Issued on November 5, 1996. Estimated Expiration Date: Icon_subject June 7, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

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Inventors

Assignee

Application

No. 486024 filed on 06/07/1995

US Classes:

210/198.2, Chromatography204/451, Capillary electrophoresis204/601, Capillary electrophoresis type210/656, Chromatography422/69, Sorption testing422/70Liquid chromatography

Examiners

Primary: Therkorn, Ernest G.

International Class

B01D 015/08

Abstract

A miniaturized total analysis system ("μ-TAS") comprising a miniaturized planar column device is described for use in liquid phase analysis. The μ-TAS comprises microstructures fabricated by laser ablation in a variety of novel support substrates. The μ-TAS includes associated laser-ablated features required for integrated sample analysis, such as analyte detection means and fluid communication means. μ-TAS constructed according to the invention is useful in any analysis system for detecting and analyzing small and/or macromolecular solutes in the liquid phase and may employ chromatographic separation means, electrophoretic separation means, electrochromatographic separation means, or combinations thereof.

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