Process for the preparation of microballs and microballs thus obtained
May 16, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References[D-Trp6 ]-LH-RH and intermediates therefor Microencapsulation of water soluble active polypeptides Continuous release pharmaceutical compositions Spheroids Spheroids Very low temperature casting of controlled release microspheres Preparation process of sustained release compositions and the compositions thus obtained Pharmaceutical composition in the form of microparticles Patent #: 5225205 InventorAssigneeApplicationNo. 243571 filed on 05/16/1994US Classes:424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/501Contains solid synthetic resinExaminersPrimary: Seidleck, James J.Assistant: Cooney, John M. Jr. Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/14Foreign Application Priority Data1993-05-15 GBAbstractA method of making microballs is disclosed. An active ingredient, a biocompatible polymer and a supporting phase, such as silicone oil, are stirred at a temperature above the Tg of the polymer and below the temperature at which any of the ingredients vaporizes or degrades. Stirring is continued until microballs of the desired diameter are formed, whereafter the mixture is cooled and the microballs are separated from the supporting phase. The microballs are substantially spherical, substantially smooth on their external surface and have substantially no active ingredient on their external surface.Other References
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