Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions
Patent 5569448 Issued on October 29, 1996. Estimated Expiration Date: 
January 24, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 24, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesAqueous hair shampoo compositions comprising sulfated ethylene oxide-propylene oxide condensates Surface modified drug nanoparticles X-ray contrast compositions useful in medical imaging Formulations comprising olin 10-G to prevent particle aggregation and increase stability Patent #: 5340564 InventorsApplicationNo. 378022 filed on 01/24/1995US Classes:424/9.45, Halogenated benzene ring containing424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/490, Coated (e.g., microcapsules)427/213.36Solid-walled microcapsule formed from preformed synthetic polymerExaminersPrimary: Mullis, JeffreyAttorney, Agent or FirmInternational ClassA61K 009/14AbstractThis invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a block copolymer linked to at least one anionic group as a surface modifier adsorbed on the surface thereof and a method of making such nanoparticles. The compositions exhibit unexpectedly improved autoclave stability, reduced macrophage uptake, improved toxicological profiles and facilitate particle size reduction such that milling time can be reduced and/or sterile filtration of the nanoparticles can be accomplished. | |
