Diltiazem controlled release formulation
March 24, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesControlled absorption diltiazen pharmaceutical formulation System for the controlled-rate release of active substances Diltiazem formulation Controlled absorption diltiazem formulation for once-daily administration Controlled absorption diltiazem formulation Controlled absorption diltiazem formulations Sustained release diltiazem formulation Multiparticulate pulsatile drug delivery system Pulsatile particles drug delivery system Diltiazem formulation InventorAssigneeApplicationNo. 409449 filed on 03/24/1995US Classes:424/494, Cellulose derivatives424/458, Containing discrete coated particles pellets, granules, or beads424/461, Containing polysaccharide (e.g., cellulose sugars, etc.)424/462, Containing solid synthetic polymers424/468, Sustained or differential release type424/496, Containing natural gums/resins424/497, Containing solid synthetic polymers514/963Microcapsule-sustained or differential releaseExaminersPrimary: Spear, James M.Attorney, Agent or FirmInternational ClassesA61K 009/58A61K 009/60 A61K 009/62 AbstractA once-a-day controlled release diltiazem formulation is described which includes:(a) from 20 to 50% by weight of enteric polymeric membrane coated pellets comprising a polymer membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder; and a second layer which comprises a membrane comprising a pH dependent polymeric material; and(b) from 50% to 80% by weight of delayed pulse polymeric membrane coated pellets comprising a polymeric membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder and a second layer which comprises a polymeric membrane which will substantially maintain its integrity in the varying pH conditions of the gastrointestinal tract but is permeable to diltiazem; and(c) a unit dose containment system.Field of SearchCoated (e.g., microcapsules)Cellulose derivatives Containing solid synthetic polymers Containing discrete coated particles pellets, granules, or beads Containing polysaccharide (e.g., cellulose sugars, etc.) Containing solid synthetic polymers Sustained or differential release type Containing natural gums/resins | |
