U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Methods for modulating the human sexual response

Patent 5565466 Issued on October 15, 1996. Estimated Expiration Date: Icon_subject August 9, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Method of effecting and enhancing an erection
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19-Oxygenated-androst-5-enes for the enhancement of libido
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Patent #: 4801587
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4885173

Method and composition for treating impotence
Patent #: 5059603
Issued on: 10/22/1991
Inventor: Rubin

Device for treatment of sexual impotence in human males
Patent #: 5065744
Issued on: 11/19/1991
Inventor: Zusmanovsky

Vaso-active medicament to treat impotence
Patent #: 5145852
Issued on: 09/08/1992
Inventor: Virag

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Inventors

Assignee

Application

No. 286615 filed on 08/09/1994

US Classes:

514/280, Pentacyclo ring system having the six-membered hetero ring as one of the cyclos514/212.01, Hetero ring is seven-membered consisting of one nitrogen and six carbons514/307, Isoquinolines (including hydrogenated)514/396, Imidazoles514/400, At imidazole ring carbon514/471, Nitrogen containing514/509, (O=)N(=O)-O-C containing (e.g., nitrate ester, etc.)514/523, Additional nitrogen other than cyano514/532, Z-C(=O)-O-Y, wherein Z contains a benzene ring514/644, Amine oxides514/649Amino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chain

Examiners

Primary: Cintins, Marianne M.
Assistant: MacMillan, Keith D.

Attorney, Agent or Firm

International Class

A61K 031/44

Abstract

The invention is directed to improved methods for modulating the human sexual response by administering a vasodilator to the circulation by a route of administration that avoids the "first-pass" effect.

Other References

  • Althof, S. E. et al., Sexual, psychological, and marital impact of self-injection of papaverine and phentolamine; a long-term prospective study, J. Sex & Marital Ther., 17(2):101-112 (1991)
  • Azadzoi, K. M. et al., Effects of Intracavernosal Trazadone Hydrochloride; Animal and Human Studies, J. Urol., 144(5):1277-1282 (1990)
  • Brindley, G. S., Cavernosal Alpha-Blockade: A New Technique for Investigating and treating Erectile Impotence, Brit. J. Psychiat., 143:332-337 (1983)
  • Brindley, G. S., Cavernosal alpha-blockade and human penile erection, J. Physiol., 342:24P (1983)
  • Brindley, G. S., Pilot experiments on the actions of drugs injected into the human corpus cavernosum penis, Br. J. Pharmac. 87: 495-500 (1986)
  • Corriere, Jr. et al., Development of Fibrotic Penile Lesions Secondary to the Intracorporeal Injection of Vasoactive Agents, J. Urol., 140:615-617 (1988)
  • Gwinup, G., Oral Phentolamine in Nonspecific Erectile Insufficiency, Ann. Int. Med., 15 Jul. 1988, 162-163
  • Larsen, E. H. et al., Fibrosis of Corpus Cavernosum after Intracavernous Injection of Phentolamine/Papaverine, J. Urol., 137:292-293 (1987)
  • Sonda, L. P. et al., The Role of Yohimbine for the Treatment of Erectile Impotence, J. Sex & Marital Ther., 16(1):15-21 (1990)
  • Virag, R., Intracavernous Injection of Papaverine for Erectile Failure, Lancet, ii:938 (1984)
  • Virag, R. et al., Intracavernous Injection of Papaverine as a Diagnostic and Therapeutic Method in Erectile Failure, Angiology, 35:79-87 (1984)
  • Zorgniotti, A. W. et al., Auto-Injection of the Corpus Cavernosum with a Vasoactive Drug Combination for Vasculogenic Impotence, J. Urol., 133:39-41 (1985
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