3-Ureidobenzodiazepinones useful as antagonists of CCK or of gastrin
Patent 5563136 Issued on October 8, 1996. Estimated Expiration Date: 
April 6, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 6, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsAssigneeApplicationNo. 211323 filed on 04/06/1994US Classes:514/221, Bicyclo ring system having the seven-membered hetero ring as one of the cyclos540/509Acyclic nitrogen bonded directly to the hetero ringExaminersPrimary: Bond, Robert T.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/55C07D 243/24 Foreign Application Priority Data1991-10-10 FRAbstractThis invention relates to compounds having formula (I), ##STR1## wherein R1 is a hydrogen or halogen atom or an alkyl, alkoxy, alkylthio, nitro, hydroxy or cyano radical; R2 is an alkyl radical or a chain --CH(R5)--CO--R6 ; R3 is (a) a phenyl radical substituted by one or a plurality of substituents selected amongst the radicals -alk-SO3 H, -alk-PO3 H2, --CH=NOH, --CH--NO-alk-COOX, --S-alk-COOX, --SO-alk-COOX, --SO2 -alk-COOX, --CH=CH--COOX, -alk-CO--NHOH, --C(=NOH)--COOX, -alk-N(OH)--CO-alk,-alk-SO2 H, --CH=CH--SO3 H, --C(COOX)=N--O-alk-COOX, tetrazolyalkyle or a group having a formula (I) or (b) a ring having the formula (A) ##STR2## wherein R9 is a radical =NOX, =NO-alk-COOX, =CH--COOX, -alk-COOX, -alk-SO2 H or -alk-S)3 H, R10 is an oxygen or sulfur atom or a methylene or alkylimino radical and R11 is a methylene or ethylene radical, R4 is a pyridyle or phenyl radical optionally substituted by one or a plurality of substituents selected amongst halogen atoms or the alkyl, alkoxy, hydroxy, carboxy, nitro and --CO--NR6 radicals, alk is an alkyl or alkylene radical and X is a hydrogen atom or an alkyl radical. The invention also discloses the salts thereof, their preparation and medicaments containing them. |
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