Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process

Patent 5560922 Issued on October 1, 1996. Estimated Expiration Date:

June 5, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Application

No. 461098 filed on 06/05/1995

US Classes:

424/448, Pressure sensitive adhesive means424/447, Bandages with incorporated medicaments424/449Transdermal or percutaneous

Examiners

Primary: Phelan, D. Gabrielle

Attorney, Agent or Firm

Schwegman, Lundberg, Woessner & Kluth, P.A.

Foreign Patent References

0127468A2 EP 12/12/1984
0156080 EP. 10/12/1985
0196769 EP. 10/12/1986
0209975 EP. 01/12/1987
0223524 EP. 05/12/1987
0224981 EP. 06/12/1987
0252712 EP. 01/12/1988
0262753 EP. 04/12/1988
0272987 EP. 06/12/1988
0275716 EP. 07/12/1988
0279977 EP. 08/12/1988
0328806 EP. 08/12/1989
0379045 EP. 07/12/1990
0416842 EP. 03/12/1991
2086224 GB. 05/12/1982

International Class

A61F 013/00

Abstract

Transdermal absorption dosage units have been developed which comprise a backing layer and an adjoining polyacrylate adhesive polymer layer in which at least minimum effective daily doses of one or more steroidal hormones are microdispersed. Presently preferred is use of the natural estrogen, 17-beta-estradiol, or ethinyl estradiol or combinations thereof together with an amount of a natural progestogen or a progestin to minimize any potential side effects. The units use bioacceptable polyacrylate adhesive polymer in making the adhesive polymer layer which has a minor percentage of vinyl acetate polymer units effective in providing improved transdermal absorption of the microdispersed steroidal hormone. An effective amount of vinyl acetate units up to about 5 percent has been found suitable. The invention also provides a process for transdermal administration of one or more steroidal hormones using the novel dosage units provided.

Other References

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