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US Patent 5554505 - Method and apparatus for optically screening microscopic cells
US Patent Issued on September 10, 1996
Estimated Patent Expiration Date:
December 1, 2013Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
December 1, 2013Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractAn optical screening method and apparatus for identifying both the morphology and selected characteristics or properties expressed by cells, such as cancer cells. The cells are combined with one or more different sets of microspheres, each set having a reactant bond thereto which will bind to a specific molecule which can exist on one or more types of cancer cells. The cells and microspheres are formed as a smear on a slide, stained with a histological type stain and optically viewed to identify the type of cells to which the different sets of microspheres do or do not bind. The different sets of microspheres are optically differentiated by having different optical characteristics, such as size, shape, color or combinations thereof. A fast cancer cell screening method or panel is provided by adding different sets of microspheres having different reactants bound thereto to different sample portions and optically screening the different sample smears. The microspheres also can be removed from a sample portion with any cells bound thereto and compared to another non-modified sample portion to ascertain if the cancer cells of interest have been removed from the sample portion.Other References
| InventorsAssigneeApplicationNo. 160986 filed on 12/01/1993US Classes:435/7.21, Animal cell435/7.2, Involving a micro-organism or cell membrane bound antigen or cell membrane bound receptor or cell membrane bound antibody or microbial lysate435/7.23, Tumor cell or cancer cell435/7.24Leukocyte (e.g., lymphocyte, granulocyte, monocyte, etc.)Field of Search435/7.2, Involving a micro-organism or cell membrane bound antigen or cell membrane bound receptor or cell membrane bound antibody or microbial lysate435/7.21, Animal cell435/7.23, Tumor cell or cancer cell435/7.24Leukocyte (e.g., lymphocyte, granulocyte, monocyte, etc.)ExaminersPrimary: Wax, Robert A.Assistant: Moore, William W. Attorney, Agent or FirmUS Patent References4029470, Automated single-slide staining deviceIssued on: 06/14/1977 Inventor: Wilkins , et al.4115535, Diagnostic method employing a mixture of normally separable protein-coated particles Issued on: 09/19/1978 Inventor: Giaever4342739, Novel material for immunological assay of biochemical components and a process for the determination of said components Issued on: 08/03/1982 Inventor: Kakimi , et al.4483928, Microcapsules sensitized with antibody and a method for measurement of lymphocyte using the same based on cell-mediated immunity Issued on: 11/20/1984 Inventor: Suzuta , et al.4511662, Simultaneous assay for T and B lymphocyte populations and subpopulations Issued on: 04/16/1985 Inventor: Baran , et al.4615878, Metachromatic dye sorption means for differential determination of sub-populations of lymphocytes Issued on: 10/07/1986 Inventor: Kass4714606, Method of staining and identifying cells and compositions thereof Issued on: 12/22/1987 Inventor: Kass5006459, Therapeutic and diagnostic methods using soluble T cell surface molecules Issued on: 04/09/1991 Inventor: Kung, et al.5340719, Method and apparatus for optically screening microscopic cells Issued on: 08/23/1994 Inventor: Hajek, et al.5348859Method and apparatus for obtaining an absolute white blood cell subset count and white blood cell multipart differential Issued on: 09/20/1994 Inventor: Brunhouse, et al. Foreign Patent References
International ClassesG01N 033/50G01N 033/80 G01N 001/28 G01N 021/00 |
