Low flux matrix system for delivering potent drugs transdermally

Patent 5554381 Issued on September 10, 1996. Estimated Expiration Date:

September 10, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Transdermal estrogen/progestin dosage unit, system and process
Patent #: 4906169
Issued on: 03/06/1990
Inventor: Chien, et al.

Transdermal acrylic multipolymer drug delivery system
Patent #: 4994267
Issued on: 02/19/1991
Inventor: Sablotsky

Transdermal absorption dosage unit for postmenopausal syndrome treatment and process for administration
Patent #: 5145682
Issued on: 09/08/1992
Inventor: Chien, et al.

Solid matrix system for transdermal drug delivery
Patent #: 5252334
Issued on: 10/12/1993
Inventor: Chiang, et al.

Method and device for the release of drugs to the skin
Patent #: 5300291
Issued on: 04/05/1994
Inventor: Sablotsky, et al.

Estrogen-containing active substance plaster Patent #: 5393529
Issued on: 02/28/1995
Inventor: Hoffmann, et al.

Inventors

Application

No. 104414 filed on 08/09/1993

US Classes:

424/449, Transdermal or percutaneous424/448, Pressure sensitive adhesive means424/487, Acrylic acid and derivatives602/54Skin or wound facing adhesive layer

Examiners

Primary: Webman, Edward J.

Attorney, Agent or Firm

Morrison and Foerster

Foreign Patent References

WO91/03219 WO. 03/14/1991

International Class

A61L 015/24

Abstract

Matrix-type transdermal drug delivery devices for administering potent steroids such as ethinyl estradiol at a low flux steady-state rate over a multi-day period comprising a laminate of: (a) an occlusive backing layer and (b) a matrix layer of the drug completely dissolved at a loading of below 0.5% by weight in a 2-ethylhexyl acrylate copolymer.