Sequencing of surface immobilized polymers utilizing microflourescence detection

Patent 5547839 Issued on August 20, 1996. Estimated Expiration Date:

August 20, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

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Inventors

Assignee

Affymax Technologies N.V.

Application

No. 626730 filed on 12/06/1990

US Classes:

435/6, Involving nucleic acid536/24.3, Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA536/24.33Primers

Examiners

Primary: Jones, W. Gary
Assistant: Houtteman, Scott W.

Attorney, Agent or Firm

Townsend & Townsend & Crew LLP

Foreign Patent References

392546 EP. 10/12/1990
2233654 GB. 01/12/1991
9013666 WO 05/12/1990
9015070 WO. 12/12/1990
9107087 WO. 05/12/1991
9106678 WO 05/12/1991

International Class

C12Q 001/68

Abstract

Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal monomers are used to label polymers at defined positions on a solid substrate.

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