Enantioselective preparation of optically pure albuterol
Patent 5545745 Issued on August 13, 1996. Estimated Expiration Date: 
January 20, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 20, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsAssigneeApplicationNo. 376072 filed on 01/20/1995US Classes:560/42, Oxy in acid moiety564/304, Of benzene ring containing compounds564/356, Preparing directly by reduction, other than by reductive amination564/363, Beta hydroxy phenethylamines (i.e., hydroxy and the benzene ring are bonded directly to the same carbon of the chain which consists of two carbons; H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)564/365Hydroxy or ether oxygen bonded directly to the aryl ring or ring system (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal)ExaminersPrimary: Raymond, Richard L.Attorney, Agent or FirmForeign Patent References
International ClassC07C 209/68AbstractThe invention relates to a method for producing albuterol by the resolution of a mixture of enantiomers of methyl 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-2-(phenylmethoxy)benzoate or -[[(1,1-dimethylethyl)amino]methyl]-4-(phenylmethoxy)-1,3-benzenedi methanol using a chiral acid such as (+/-) di-toluoyltartaric acid or (+/-) di-benzoyltartaric acid.Other References
Field of SearchOxy in acid moietyOf benzene ring containing compounds Preparing directly by reduction, other than by reductive amination Beta hydroxy phenethylamines (i.e., hydroxy and the benzene ring are bonded directly to the same carbon of the chain which consists of two carbons; H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal) Hydroxy or ether oxygen bonded directly to the aryl ring or ring system (H of -OH may be replaced by a substituted or unsubstituted ammonium ion or a Group IA or IIA light metal) |
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