Conjugates for the prevention and treatment of sepsis
Patent 5545721 Issued on August 13, 1996. Estimated Expiration Date: December 17, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
530/391.7, Conjugated to a cytotoxic agent, drug, or other biologically-active substance530/300, PEPTIDES OF 3 TO 100 AMINO ACID RESIDUES530/317, Cyclic peptides530/319, Polymyxin; related peptides530/322, Peptides containing saccharide radicals, e.g., bleomycins, etc.530/345, Chemical aftertreatment, e.g., acylation, methylation, etc.530/350, PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES530/391.1, Monoclonal or polyclonal antibody or immunoglobulin or fragment thereof that is conjugated or adsorbed (e.g., adsorbed to a solid support, etc.)530/391.5, Conjugated via a specifically-identified linking group, chelating group, coordination complex, coupling agent, or conjugation agent530/391.9, Conjugated via a specifically-identified linking group, coupling agent, or conjugation agent530/402Chemical modification or the reaction product thereof, e.g., covalent attachment or coupling, etc.
Compositions and methods are described for preventing and treating sepsis in humans and other animals. Surgical patients, low birth weight infants, burn and trauma victims, as well as other individuals at risk can be treated prophylactically. Methods for treating acute infections with advantages over current therapeutic approaches are provided. Conjugates and methods of making conjugates for the prevention and treatment of sepsis are described.
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