U.S. patents available from 1976 to present.
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Certain tetrahydrocannabinol-7-oic acid derivatives

Patent 5538993 Issued on July 23, 1996. Estimated Expiration Date: Icon_subject February 7, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Novel tetrahydrocannabinol type compounds
Patent #: 4179517
Issued on: 12/18/1979
Inventor: Mechoulam ,   et al.

Delta 1-thc-7-oic acid and analgesic and anti-inflammatory agents
Patent #: 4847290
Issued on: 07/11/1989
Inventor: Burstein

(3S-4S)-7-hydroxy-Ɗ6 -tetrahydrocannabinols
Patent #: 4876276
Issued on: 10/24/1989
Inventor: Mechoulam, et al.

Deuterated cannabinoids as standards for the analysis of tetrahydrocannabinol and its metabolites in biological fluids
Patent #: 5036014
Issued on: 07/30/1991
Inventor: ElSohly, et al.

Fluorescene polarization immunoassay for tetrahydrocannabinoids Patent #: 5144030
Issued on: 09/01/1992
Inventor: Wang, et al.

Inventors

Assignee

Application

No. 192923 filed on 02/07/1994

US Classes:

514/454, Tricyclo ring system having the hetero ring as one of the cyclos549/390Dibenzo(b,d)pyrans (including hydrogenated)

Examiners

Primary: Richter, Johann
Assistant: Peabody, John

Attorney, Agent or Firm

International Classes

A61K 031/35
C07D 311/80

Foreign Application Priority Data

1991-09-14 IL

Abstract

The invention relates to compounds of the formula ##STR1## having the (3S,4S) configuration and being essentially free of the (3R,4R) enantiomer, in which A--B indicates an optional 1(2) or 6(1) double bond, X is carboxy, carbalkoxy, or carboxamido, linked to the ring directly or through an alkylene linkage, G is halogen, alkyl, or oxy, and Y is alkyl, oxy, or oxyalkylene. The invention further relates to the synthesis of such compounds, and to pharmaceutical compositions and therapeutic methods in which such compounds may be employed.

Other References

  • Mechoulam et al., Tetrahedron: Asymmetry, vol. 1, No. 5, pp. 315-318 (1990)
  • Feigenbaum et al., Proc. Natl. Acad. Sci. USA, vol. 86, pp. 9584-9587 (1989)
  • Schwartz et al., J. Org. Chem., vol. 51, pp. 5463-5465 (1986
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