Methods and compositions to enhance epithelial drug transport
Patent 5534496 Issued on July 9, 1996. Estimated Expiration Date: 
March 29, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 29, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesSuppository preparation having excellent absorption property Patent #: 4873087 InventorsAssigneeApplicationNo. 219156 filed on 03/29/1994US Classes:514/17, 5 or 6 peptide repeating units in known peptide chain424/434, Mucosal (e.g., nasal, etc.)514/18, 3 or 4 peptide repeating units in known peptide chain514/19, 2 peptide repeating units in known peptide chain530/330, 4 to 5 amino acid residues in defined sequence530/331Tripeptides, e.g., tripeptide thyroliberin (TRH), melanostatin (MIF), etc.ExaminersPrimary: Chan, ChristinaAssistant: Lukton, David Attorney, Agent or FirmInternational ClassA61K 038/08AbstractMethods and compositions provided for enhancing the transport of drugs (including peptides, oligonucleotides, proteins and conventional drugs) across epithelial cells at mucosal sites. The methods and compositions include the use of a peptide comprising at least two amino acids, such as Pro-Leu-Gly-Pro-Arg or Pro-Leu, and a protective group such as phenylazo-benzyloxycarbonyl, N-methyl, t-butyloxycarbonyl, fluoroenylmethyloxycarbonyl or carbobenzoxy, at the N-terminus, or in a mixture of such peptides in a sufficient amount to enhance the drug transport across epithelial cells at mucosal sites. Preferably, the peptide comprises 2 to 5 amino acids; the N-terminal amino acids are preferably Pro-Leu. The peptide with the drug are introduced to the mucosal site in a physical mixture, a conjugated form or by a microcapsule, microsphere, liposome, cell, bacteria, virus or food vesicle carrier by an oral, nasal, pulmonary, buccal, rectal, transdermal, vaginal or ocular route.Other References
Field of SearchMucosal (e.g., nasal, etc.)5 or 6 peptide repeating units in known peptide chain 3 or 4 peptide repeating units in known peptide chain 2 peptide repeating units in known peptide chain 4 to 5 amino acid residues in defined sequence Tripeptides, e.g., tripeptide thyroliberin (TRH), melanostatin (MIF), etc. |
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