Method of preparing stable drug nanoparticles
Patent 5534270 Issued on July 9, 1996. Estimated Expiration Date: 
February 9, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 9, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesSurface modified anticancer nanoparticles Iodinated aroyloxy ketones Patent #: 5488133 InventorAssigneeApplicationNo. 386028 filed on 02/09/1995US Classes:424/490, Coated (e.g., microcapsules)424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/494, Cellulose derivatives424/497Containing solid synthetic polymersExaminersPrimary: Mullis, JeffreyAttorney, Agent or FirmInternational ClassA61K 009/14AbstractStable dispersible particles consisting essentially of a crystalline drug substance having a surface modifier adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 400 nm are prepared by providing a drug substance, depyrogenating grinding media, mixing the drug substance, grinding media and autoclaving and adding a surface modifier either during autoclaving or after autoclaving and subsequently wet milling. Pharmaceutical compositions containing the particles exhibit unexpected bioavailability and are useful in methods of treating mammals. | |
