Pharmaceutical granulated composition and method for preparing same

Patent 5534262 Issued on July 9, 1996. Estimated Expiration Date:

September 10, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3063900

L-ascorbic acid tablets
Patent #: 4036948
Issued on: 07/19/1977
Inventor: Kitamori , et al.

Sustained release tablet containing at least 95 percent theophylline
Patent #: 4465660
Issued on: 08/14/1984
Inventor: David , et al.

Water-soluble sweetening tablets
Patent #: 4486455
Issued on: 12/04/1984
Inventor: Wolf , et al.

Granules of thiamine salt and the production thereof
Patent #: 4702919
Issued on: 10/27/1987
Inventor: Kitamori , et al.

Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content
Patent #: 4748023
Issued on: 05/31/1988
Inventor: Tamas , et al.

Sustained release pharmaceutical compositions Patent #: 4973470
Issued on: 11/27/1990
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Inventors

Application

No. 119049 filed on 09/10/1993

US Classes:

424/464, Tablets, lozenges, or pills424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)514/772.3, Solid synthetic organic polymer514/778, Starch or derivative514/781, Cellulose or derivative514/784, Carboxylic acid or salt thereof514/960, SIGNIFICANT, TABLET FORMULATION (E.G., DESIGNATED EXCIPIENT, DISINTEGRANT, GLYDENT OR LUBRICANT, ETC.)514/961Binder therefor

Examiners

Primary: Page, Thurman K.
Assistant: Spear, James M.

Attorney, Agent or Firm

Ladas & parry

Foreign Patent References

0219276 EP. 04/13/1987

International Classes

A61K 009/16
A61K 009/20
A61K 031/195

Abstract

A granulated composition for direct tableting, comprising non-pressed or difficulty pressed, water-soluble, crystalline pharmaceutical substances, binder, lubricant and water, contains at least 98 wt. % of a pharmaceutically active component. The tablets manufactured from said composition have high hardness and the controllable time of dissolution. A method for preparing said composition consists in that the powder of a pharmaceutical substance is pre-granulated with water or its aqueous solution, the resultant granulate is then subjected to subsequent granulation with a binder solution, dried and powdered with lubricant.