U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin

Patent 5532278 Issued on July 2, 1996. Estimated Expiration Date: Icon_subject January 31, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

5236956

Transdermal administration of oxybutynin Patent #: 5411740
Issued on: 05/02/1995
Inventor: Lee, et al.

Inventors

Assignee

Application

No. 381542 filed on 01/31/1995

US Classes:

514/617, R contains benzene ring424/449, Transdermal or percutaneous424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/464, Tablets, lozenges, or pills514/946PENETRANT OR ABSORBENT (ENHANCES PENETRATION INTO SUBJECT TREATED)

Examiners

Primary: Rollins, John W.

Attorney, Agent or Firm

Foreign Patent References

  • 940540 GB. 07/13/1961
  • 92/20377 WO. 05/13/1992

International Classes

A61K 031/165
A61K 009/70

Abstract

A method for treating urinary incontinence while avoiding concomitant liability of adverse effects associated with racemic oxybutynin is disclosed. The method comprises administering a therapeutically effective amount of (S)-oxybutynin or a pharmaceutically acceptable salt thereof, substantially free of its R enantiomer. Pharmaceutical compositions comprising (S)-oxybutynin and an acceptable carrier are also disclosed.

Other References

  • Lish et al. "Oxybutynin--A Musculotropic Antispasmodic Drug . . . " Arch. int. Pharmacodyn. 156, 456-488 (1965)
  • Hock "Clinical Evaulation of Oxybutynin Chloride" Current Therapeutic Research 9, 437-440 (1967)
  • Fredericks et al. "A Study of the Anticholinergic and Antispasmodic Activity of Oxybutynin . . . " Investigative Urology 12, 317-319 ((1975)
  • Nilvebrant et al. "Dicyclomine, Benzhexol and Oxybutynine Distinguish . . . " Europ. J. Pharmacol. 123, 133-143 (1986)
  • Tonini et al. "Depressant action of oxybutynin on the contractility . . . " J. Pharm. Pharmacol. 39, 103-107 (1986)
  • Kachur et al. "R and S Enantiomers of Oxybutynin: Pharmacological Effects . . . " J. Pharm. Exper. Ther. 247, 867-872 (1988)
  • Noronha-Blob et al. "Muscarinic Receptors: Relationships Among Phosphoinositide . . . " J. Pharm. Exper. Ther. 249, 843-851 (1989)
  • Noronha-Blob et al. "The Anticholinergic Activity of Agents Indicated for Urinary . . . " J. Pharm. Exper. Ther. 251, 586-593 (1989)
  • Peterson et al. "In Vivo Cystometrogram Studies in Urethane-Anesthetized and Conscious Guinea Pigs" J. Pharm. Methods 21, 231-241 (1989)
  • Guarneri et al. "Effects of Oxybutynin, Terodiline, and Nifedipine . . . " Pharm. Research 24, 263-272 (1991)
  • Noronha-Blob et al. "Enantiomers of Oxybutynin: In Vitro Pharmacological Characterization . . . " J. Pharm. Exp. Ther. 256, 562-567 (1990)
  • Lowe et al. "Effect of extracellular CA2+ on cholinergic, KCl and phorbol ester-mediated . . . " Eur. J. Pharm. 195, 273-279 (1991)
  • Massad et al. "The Pharmacokinetics of Intravesical and Oral Oxybutynin Chloride" J. Urology 148, 595-597 (1992)
  • Angelico et al. "In Vivo Effects of Different Antispasmodic Drugs on the Rat Bladder Contractions" J. Pharm. Methods 27, 33-39 (1992)
  • Guarneri et al. "Effects of Drugs Used in the Therapy of Detrusor Hyperactivity . . . " Pharm. Research 27, 173-187 (1993
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
PatentsPlus: add to cart
PatentsPlus: add to cartIntelligent turbocharged patent PDFs with marked up images
$18.95more info
 
Sign InRegister
Username  
Password   
forgot password?