U.S. patents available from 1976 to present.
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Particles, method of preparing said particles and uses thereof

Patent 5531925 Issued on July 2, 1996. Estimated Expiration Date: Icon_subject April 11, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Low birefringence encapsulated liquid crystal and optical shutter using same
Patent #: 4556289
Issued on: 12/03/1985
Inventor: Fergason

Structured aqueous detergent compositions containing salting-out electrolytes and surfactants and methods of forming them
Patent #: 5021195
Issued on: 06/04/1991
Inventor: Machin, et al.

Dispensing devices powered by lyotropic liquid crystals
Patent #: 5030452
Issued on: 07/09/1991
Inventor: Curatolo

Dispensing devices powered by lyotropic liquid crystals
Patent #: 5108756
Issued on: 04/28/1992
Inventor: Curatolo

Method and composition for controlled delivery of biologically active agents
Patent #: 5143934
Issued on: 09/01/1992
Inventor: Lading, et al.

Method of preparing controlled-release preparations for biologically active materials and resulting compositions
Patent #: 5151272
Issued on: 09/29/1992
Inventor: Engstrom, et al.

Controlled release composition for a biologically active material dissolved or dispersed in an L2-phase Patent #: 5371109
Issued on: 12/06/1994
Inventor: Engstrom, et al.

Inventors

Assignee

Application

No. 211293 filed on 04/11/1994

US Classes:

252/299.01, LIQUID CRYSTAL COMPOSITIONS424/1.21, Molecular bilayer structure (e.g., vesicle, liposome)424/450, Liposomes424/455, Containing emulsions, dispersions, or solutions428/402, Particulate matter (e.g., sphere, flake, etc.)435/4, MEASURING OR TESTING PROCESS INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITION OR TEST STRIP THEREFORE; PROCESSES OF FORMING SUCH COMPOSITION OR TEST STRIP514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI514/937, DISPERSION OR EMULSION514/964, SUSTAINED OR DIFFERENTIAL RELEASE TYPE516/56, The agent contains organic compound containing phosphorus (e.g., lecithin)516/70, The compound contains plural peptide linkages, i.e., compound formed from amino acids, natural or synthetic, by reaction of a carboxyl group of one such amino acid with an amino group of another same or different such amino acid516/76, The compound contains repeating -(OCnH2n)- (i.e., repeating unsubstituted oxyalkylene)516/900LIQUID CRYSTAL MATERIAL OF, OR FOR, COLLOID SYSTEM (E.G., G PHASE)

Examiners

Primary: Wu, Shean C.

Attorney, Agent or Firm

Foreign Patent References

  • 0119867 EP. 09/12/1984
  • 0378403 EP. 07/12/1990
  • 03139525A JP. 06/12/1991
  • WO84/02076 WO. 06/12/1984

International Classes

C09K 019/00
A61K 009/66
B01J 013/00

Abstract

Particles, especially colloidal particles, comprising an interior phase of a non-lamellar reversed cubic, intermediate or hexagonal liquid crystalline phase, or a homogeneous L3 phase, and a surface phase of a lamellar crystalline or liquid crystalline phase, or an L3 phase. A method of preparing such particles by creating a local dispersible phase, within the homogeneous phase, preferably by means of a fragmentation agent, and fragmentating the homogeneous phase so as to form said surface phase. Several medical as well as non-medical uses of the particles referred to, e.g. as an antigen-presenting system, as a delivery system for anticancer, antifungal and antimicrobial drugs, and as carriers of nucleic acids or nucleotides.

Other References

  • "Drug Delivery from Cubic and Other Lipid-Water Phases", Sven Engstrom, Lipid Technology, vol. 2, No. 2, pp. 42-45 (Apr. 1990
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