Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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AbstractAn extended-release galenical form of Diltiazem or a pharmaceutically acceptable salt thereof, which comprises beads containing said Diltiazem or a pharmaceutically acceptable salt thereof as an active ingredient and a wetting agent, said beads being coated with a microporous membrane comprising at least a water-soluble or water-dispersible polymer or copolymer and a pharmaceutically acceptable adjuvant. | InventorsAssigneeApplicationNo. 311722 filed on 09/23/1994US Classes:424/494, Cellulose derivatives424/490, Coated (e.g., microcapsules)424/497, Containing solid synthetic polymers514/777, Carbohydrate or lignin, or derivative514/785, Carboxylic acid ester514/786, Glyceride514/970CONTAINING DESIGNATED INGREDIENT TO STABILIZE AN ACTIVE INGREDIENTField of Search424/457, Sustained or differential release424/458, Containing discrete coated particles pellets, granules, or beads424/462, Containing solid synthetic polymers424/490, Coated (e.g., microcapsules)424/493, Containing polysaccharides (e.g., sugars)424/497, Containing solid synthetic polymers424/498, Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof424/499, Contains proteins or derivative or polysaccharides or derivative424/494Cellulose derivativesExaminersPrimary: Page, Thurman K.Assistant: Spear, James M. Attorney, Agent or FirmUS Patent References5112621, Sustained release pharmaceutical composition of diltiazemIssued on: 05/12/1992 Inventor: Stevens, et al.5275824Therapeutic compositions with controlled release of medicaments supported on crosslinked polymers and coated with polymer films, and their preparation process Issued on: 01/04/1994 Inventor: Carli, et al. International ClassesA61K 009/16A61K 009/58 A61K 009/62 |