U.S. patents available from 1976 to present.
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Detection of human papillomavirus by the polymerase chain reaction

Patent 5527898 Issued on June 18, 1996. Estimated Expiration Date: Icon_subject June 7, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Human papillomavirus 35 nucleic acid hybridization probes and methods for employing the same
Patent #: 4849332
Issued on: 07/18/1989
Inventor: Lorincz

Human papillomavirus 56 nucleic acid hybridization probes and methods for employing the same
Patent #: 4908306
Issued on: 03/13/1990
Inventor: Lorincz

Type-specific papillomavirus DNA sequences and peptides
Patent #: 5057411
Issued on: 10/15/1991
Inventor: Lancaster, et al.

Human papilloma virus type 57 and the DNA thereof Patent #: 5187090
Issued on: 02/16/1993
Inventor: de Villiers, et al.

Inventors

Assignee

Application

No. 474542 filed on 06/07/1995

US Classes:

536/24.3, Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA435/5, Involving virus or bacteriophage435/6, Involving nucleic acid435/91.1, Polynucleotide (e.g., nucleic acid, oligonucleotide, etc.)435/91.2, Acellular exponential or geometric amplification (e.g., PCR, etc.)436/501, BIOSPECIFIC LIGAND BINDING ASSAY536/23.1, DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)536/24.1, Non-coding sequences which control transcription or translation processes (e.g., promoters, operators, enhancers, ribosome binding sites, etc.)536/24.31, Probes for detection of animal nucleotide sequences536/24.32, Probes for detection of microbial nucleotide sequences536/24.33Primers

Examiners

Primary: Jones, W. Gary
Assistant: Marschel, Ardin H.

Attorney, Agent or Firm

Foreign Patent References

  • 9211369 WO. 07/13/1992
  • 9300435 WO. 01/13/1993

International Classes

C07H 021/04
C12Q 001/68

Abstract

The presence of human papillomavirus (HPV) in a sample can be detected and the HPV typed by a method that involves the amplification of HPV DNA sequences by the polymerase chain reaction (PCR). The primers used in the method are consensus primers that can be used to amplify a particular region of the genome of any HPV. The presence of HPV in a sample is indicated by the formation of amplified DNA. The HPV nucleic acid is detected by consensus probes that may be short oligonucleotide probes or long generic probes. The HPV is typed by the use of type-specific DNA probes specific for the amplified region of DNA.

Other References

  • De Villiers (1989) J of Virology, vol. 63, No. 11, pp. 4898-4903
  • Deluis et al. (1993) GenBank accession X74472 of "Human papillomavirus type 26 genomic DNA"
  • Seedorf et al., 1985, "Human Papillomavirus Type 16 DNA Sequence" Virology 145:181-185
  • Cole and Streeck, 1986, "Genome Organization and Nucleotide Sequence of Human Papillomavirus Type 33, Which is Associated With Cervical Cancer" J. Virology 58(3):991-995
  • Dartmann et al., 1986, "The Nucleotide Sequence and Genome Organization of Human Papilloma Virus Type 11" Virology 151:124-130
  • Cole and Danos, 1987, "Nucleotide Sequence and Comparative Analysis of the Human Papillomavirus Type 18 Genome" J. Mol. Biol. 193:599-608
  • Shibata et al., 1988, "Detection of Human Papilloma Virus in Paraffin-Embedded Tissue Using the Polymerase Chain Reaction" J. Exp. Med. 167:255-230
  • Goldsborough et al., 1989, "Nucleotide Sequence of Human Papillomavirus Type 31: A Cervical Neoplasia-Associated Virus" Virology 171:306-311
  • Resnick et al., 1990, "Detection and Typing of Human Papillomavirus in Archival Cervical Cancer Specimens by DNA Amplification With Consensus Primers" J. Natl. Cancer Institute 82(18):1477-1484
  • Bauer et al., Diagnostic Molecular Pathology a Practical Approach, vol. 2, Chapter 6, entitled "Determination of Genital Human Papillomavirus Infection by Consensus PCR Amplification" pp. 131-152, Ed. C. S. Herrington and J. O'DMcGee, 1992
  • Ostrow et al, 1984, "Molecular Cloning and Characterization of a Unique Type of Human Papillomavirus from an Immune Deficient Patient" J. Invest. Dermatology 82:362-366
  • Lorincz et al., 1987, "A New Type of Papillomavirus Associated with Cancer of the Uterine Cervix" Virology 159:187-190
  • Hirsch-Behnam et al., 1990, "A Comparative Sequence Analysis of Two Human Papillomavirus (HPV) Types 2a and 57" Virus Research 18:81-98
  • Kirii et al., 1991, "Human Papillomavirus Type 58 DNA Sequence" Virology 185:424-427
  • Lungu et al., Aug., 1991, "Biologic Properties and Nucleotide Sequence Analysis of Human Papillomavirus Type 51" J. Virology 65:4216-4225
  • Reuter et al., Oct., 1991, "Characterization of a Novel Human Papillomavirus DNA in the Cervical Carcinoma Cell Line ME180" J. Virology 65:5564-5568
  • Volpers and Streeck, 1991, "Genome Organization and Nucleotide Sequence of Human Papillomavirus Type 39" Virology 181:419-423
  • Marich et al., 1992, "The Phylogenetic Relationship and Complete Nucleotide Sequence of Human Papillomavirus Type 35" 186:770-776
  • Philipp et al., 1992, "Human Papillomavirus Type 42: New Sequences, Conserved Genome Organization" Virology 186:331-33
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