U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

NMDA-blocking pharmaceuticals

Patent 5521215 Issued on May 28, 1996. Estimated Expiration Date: Icon_subject February 7, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
Patent #: 4133819
Issued on: 01/09/1979
Inventor: Johnson

Novel tetrahydrocannabinol type compounds
Patent #: 4179517
Issued on: 12/18/1979
Inventor: Mechoulam ,   et al.

Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
Patent #: 4209520
Issued on: 06/24/1980
Inventor: Johnson

(3S-4S)-7-hydroxy-Ɗ6 -tetrahydrocannabinols Patent #: 4876276
Issued on: 10/24/1989
Inventor: Mechoulam, et al.

Inventors

Assignee

Application

No. 192886 filed on 02/07/1994

US Classes:

514/454Tricyclo ring system having the hetero ring as one of the cyclos

Examiners

Primary: Chan, Nicky

Attorney, Agent or Firm

Foreign Patent References

  • 28 26 849 DE. 12/11/1978

International Class

A61K 031/35

Foreign Application Priority Data

1989-11-07 IL

Abstract

Pharmaceutical compositions are described for preventing neurotoxicity, crising as active ingredient the stereospecific (+) enantiomer, having (3S,4S) configuration of Ɗ6 tetrahydrocannabinol type compounds. The compositions are particularly effective in alleviating and even preventing neurotoxicity due to acute injuries to the central nervous system, including mechanical trauma, compromised or reduced blood supply as may occur in cardiac arrest or stroke, or poisonings. They are also effective in the treatment of certain chronic degenerative diseases characterized by gradual neuronal loss.

Other References

  • Mechoulam et al., Tetrahedron Asymmetry 1:315-319 (1990)
  • Choi, Neuron 1:623-624 (1988)
  • Kloog et al., Biochemistry 27:843-848 (1988)
  • Mechoulam et al., Experientia 44:762-764 (1988)
  • Feigenbaum et al., Pharmacol. Biochem. Behav. 16:235-240 (1982
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