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US Patent 5521215 - NMDA-blocking pharmaceuticals

US Patent Issued on May 28, 1996
Estimated Patent Expiration Date: Icon_subject February 7, 2014Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

Pharmaceutical compositions are described for preventing neurotoxicity, crising as active ingredient the stereospecific (+) enantiomer, having (3S,4S) configuration of Ɗ6 tetrahydrocannabinol type compounds. The compositions are particularly effective in alleviating and even preventing neurotoxicity due to acute injuries to the central nervous system, including mechanical trauma, compromised or reduced blood supply as may occur in cardiac arrest or stroke, or poisonings. They are also effective in the treatment of certain chronic degenerative diseases characterized by gradual neuronal loss.

Other References

  • Mechoulam et al., Tetrahedron Asymmetry 1:315-319 (1990)
  • Choi, Neuron 1:623-624 (1988)
  • Kloog et al., Biochemistry 27:843-848 (1988)
  • Mechoulam et al., Experientia 44:762-764 (1988)
  • Feigenbaum et al., Pharmacol. Biochem. Behav. 16:235-240 (1982

Inventors

Assignee

Application

No. 192886 filed on 02/07/1994

US Classes:

514/454Tricyclo ring system having the hetero ring as one of the cyclos

Field of Search

549/454, The chalcogen, X, is in a -C(=X)- group549/390, Dibenzo(b,d)pyrans (including hydrogenated)514/454Tricyclo ring system having the hetero ring as one of the cyclos

Examiners

Primary: Chan, Nicky

Attorney, Agent or Firm

US Patent References

4133819, Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
Issued on: 01/09/1979
Inventor: Johnson
4179517, Novel tetrahydrocannabinol type compounds
Issued on: 12/18/1979
Inventor: Mechoulam ,   et al.
4209520, Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
Issued on: 06/24/1980
Inventor: Johnson
4876276(3S-4S)-7-hydroxy-Ɗ6 -tetrahydrocannabinols
Issued on: 10/24/1989
Inventor: Mechoulam, et al.

Foreign Patent References

  • 28 26 849 DE. 12/13/1978

International Class

A61K 031/35

Foreign Application Priority Data

1989-11-07 IL

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