Heterocyclic amides
Patent 5521179 Issued on May 28, 1996. Estimated Expiration Date: 
May 28, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 28, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesLactam containing compounds, their pharmaceutical compositions and method of use Peptide derivatives Patent #: 4910190 InventorsAssigneeApplicationNo. 045009 filed on 04/08/1993US Classes:514/235.5, Ring nitrogen in the additional hetero ring514/236.8, Ring chalcogen in the additional hetero ring (e.g., oxazole, etc.)514/247, Hetero ring is six-membered consisting of two nitrogens and four carbon atoms (e.g., pyridazines, etc.)514/346, Chalcogen and acyclic nitrogen bonded directly to the same carbon514/349, Nitrogen attached directly to the six-membered hetero ring by nonionic bonding544/224, The six-membered hetero ring consists of two nitrogens and four carbons (e.g., 1,2-diazines, etc.)544/360, Six-membered ring consisting of one nitrogen and five carbons (e.g., pyridine, etc.)544/362, The additional six-membered hetero ring is one of the cyclos in a bicyclo ring system546/23, Polycyclo ring system having the six-membered hetero ring as one of the cyclos546/24, Chalcogen bonded directly to ring carbon of the six-membered hetero ring546/174, Having -C(=X)-, wherein X is chalcogen, attached indirectly to the quinoline ring system by nonionic bonding546/175, Nitrogen bonded directly to the -C(=X)- group546/193, Pyridine ring or partially hydrogenated pyridine ring546/256, Additional hetero ring containing546/268.4, The additional hetero ring is five-membered having two or more ring hetero atoms of which at least one is nitrogen546/269.7, 1,3-thiazoles (including hydrogenated)546/270.4, 1,3-thiazole ring bonded directly to the six-membered hetero ring546/270.7, Nitrogen attached directly to the 1,3-thiazole ring by nonionic bonding546/271.4, 1,3-oxazoles (including hydrogenated)546/271.7, Polycyclo ring system having the 1,3-oxazole ring as one of the cyclos546/272.7, 1,3-diazoles (including hydrogenated)546/274.1, The 1,3-diazole ring is bonded directly to the six-membered hetero ring546/274.4, Chalcogen attached directly to the 1,3-diazole ring by nonionic bonding546/274.7, Nitrogen or -C(=X)-, wherein X is chalcogen, attached directly to the 1,3-diazole diazole ring by nonionic bonding546/277.1, Bicyclo ring system which is isoindole (including hydrogenated)546/277.4, Bicyclo ring system which is indole (including hydrogenated)546/277.7, Chalcogen attached directly to the five-membered hetero ring by nonionic bonding546/278.1, Having -C(=X)-, wherein X is chalcogen, bonded directly to the five- membered hetero ring546/278.4, Chalcogen attached directly to the five-membered hetero ring by nonionic bonding546/278.7, Plural chalcogens attached directly to the five-membered hetero ring by nonionic bonding546/279.1, Nitrogen or -C(=X)-, wherein X is chalcogen, attached directly to the five- membered ring by nonionic bonding546/281.4, Nitrigen attached directly to the six-membered hetero ring or to the additional hetero ring by nonionic bonding546/282.1, The additional hetero ring is six-membered546/282.4, Plural ring oxygens in the additional hetero ring546/283.4, The additional hetero ring is five-membered546/284.4, Chalcogen attached directly to the additional hetero ring by nonionic bonding546/284.7, Nitrogen or -C(=X)-, wherein X is chalcogen, attached directly to the additional hetero ring by nonionic bonding546/291Chalcogen and acyclic nitrogen bonded directly to the same carbonExaminersPrimary: Ivy, C. WarrenAssistant: Compton, Raymond Attorney, Agent or FirmForeign Patent References
International ClassesC07D 237/00C07D 211/72 C07D 401/00 C07D 215/14 Foreign Application Priority Data1991-04-18 GBAbstractThe present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.Other References
Field of SearchThe chalcogen or the acyclic nitrogen is bonded directly to the six membered hetero ringHaving -C(=X)-, wherein X is chalcogen, attached indirectly to the quinoline ring system by nonionic bonding Nitrogen bonded directly to the -C(=X)- group The six-membered hetero ring consists of two nitrogens and four carbons (e.g., 1,2-diazines, etc.) Six-membered ring consisting of one nitrogen and five carbons (e.g., pyridine, etc.) The additional six-membered hetero ring is one of the cyclos in a bicyclo ring system Ring nitrogen in the additional hetero ring Ring chalcogen in the additional hetero ring (e.g., oxazole, etc.) Hetero ring is six-membered consisting of two nitrogens and four carbon atoms (e.g., pyridazines, etc.) Chalcogen and acyclic nitrogen bonded directly to the same carbon Nitrogen attached directly to the six-membered hetero ring by nonionic bonding |
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