Preparation of diagnostic agents
Patent 5518709 Issued on May 21, 1996. Estimated Expiration Date: 
May 21, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 21, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 2797201 3501419 Method for incorporating substances into protein microspheres Method of preparing microcapsules Injectable compositions, nanoparticles useful therein, and process of manufacturing same Process for the preparation of hollow particulates Albumin medicament carrier system Intravascularly-administrable, magnetically-localizable biodegradable carrier Ultrasonic image enhancement Flow rate measurement InventorsAssigneeApplicationNo. 956875 filed on 03/15/1993US Classes:424/9.52, Stable gas bubbles containing or intentional solubilized gas containing106/158.1, Albumin or derivative106/159.1, Casein or derivative106/160.1, Gelatin or collagen or derivative (e.g., glue, etc.)252/363.5, SOLIDS WITH SOLUTION OR DISPERSION AIDS516/77, Aqueous continuous liquid phase and discontinuous phase primarily solid (e.g., water based suspensions, dispersions, or certain sols*, of natural or synthetic ester-wax, beeswax, carnauba wax; or latex dispersion)600/437, Ultrasonic600/438, Used as an indicator of another parameter (e.g., temperature, pressure, viscosity)600/441, Having B-scan and Doppler600/450, Cardiographic600/458Contrast enhancementExaminersPrimary: Lovering, Richard D.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 049/00A61B 008/00 A61B 008/02 Foreign Application Priority Data1991-04-10 GBAbstractMicrocapsules are prepared by a process comprising the steps of (i) spray-drying a solution or dispersion of a wall-forming material in order to obtain intermediate microcapsules and (ii) reducing the water-solubility of at least the outside of the intermediate microcapsules.Suitable wall-forming materials include proteins such as albumin and gelatin.The microcapsules have walls of 40-500 nm thick and are useful in ultrasonic imaging. The control of median size, size distribution and degree of insolubilization and cross-linking of the wall-forming material allows novel microsphere preparations to be produced.Other References
Field of SearchWith treatment subsequent to solid wall formation (e.g., coating, hardening, etc.)Solid-walled microcapsule formed by physically removing a constituent (e.g., evaporation, extraction, etc.) Microcapsule with fluid core (includes liposome) Stable gas bubbles containing or intentional solubilized gas containing | |
