Methods and apparatus allowing sequential chemical reactions
May 14, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3338812 3717436 3725010 Peptide or protein sequencing method and apparatus Process and apparatus for conversion of atz to pth amino acid derivatives of proteins Method for the sequential performance of chemical processes Conversion flask for sequential performance apparatus Method of sequencing peptides Apparatus for the sequential performance of chemical processes Methods for use in the mass analysis of chemical samples InventorsAssigneeApplicationNo. 842363 filed on 04/30/1992US Classes:436/89, Amino acid or sequencing procedure204/450, Electrophoresis or electro-osmosis processes and electrolyte compositions therefor when not provided for elsewhere204/451, Capillary electrophoresis204/452, With detailed detection436/180Volumetric liquid transferExaminersPrimary: Snay, JeffreyAttorney, Agent or FirmForeign Patent References
International ClassesG01N 027/30G01N 027/447 Foreign Application Priority Data1990-04-11 AUAbstractA first reactant is immobilized i.e. in a porous matrix (50), adjacent a sample electrode (46) within a reaction chamber. Energizing of the electrode (46) electrophoretically attracts a mobile second reactant and/or electrolytically induces appropriate reaction conditions to enhance reaction of the first and second reactants. Polarity reversals between the sample electrode (46) and remote electrodes (38), (42), (44) cause unreacted second reactant and/or by-products to migrate away from the immobilized first reactant. The techniques are useful for sequential chemical reactions such as sequencing or construction of proteins, polysaccharides and nucleic acids where cyclical additions and removals of reactants are required. The techniques are amenable to automated micro and nano scale construction and operation and allow direct electrophoretic (38) interfacing with chromatographic, HPCE and mass spectrophotometric equipment.Field of SearchPEPTIDE, PROTEIN OR AMINO ACIDGlycoproteins (e.g., hormone, etc.) Albumin Amino acid or sequencing procedure Alpha or beta amino acid MEASUREMENT OF ELECTRICAL OR MAGNETIC PROPERTY OR THERMAL CONDUCTIVITY Of a liquid By means of a solid body in contact with a fluid INCLUDING CHROMATOGRAPHY NUCLEAR MAGNETIC RESONANCE, ELECTRON SPIN RESONANCE OR OTHER SPIN EFFECTS OR MASS SPECTROMETRY Digestion or removing interfering materials Liberation or purification of sample or separation of material from a sample (e.g., filtering, centrifuging, etc.) Including use of a solid sorbent, semipermeable membrane, or liquid extraction Volumetric liquid transfer Including means for separating a constituent; e.g., filter, condenser, extractor, etc. Measuring electrical property Resistance or conductivity Electrostatic field or electrical discharge With specific analytical program control means |
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