Aromatic amine derivatives
Patent 5508306 Issued on April 16, 1996. Estimated Expiration Date: 
September 9, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 9, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesSubstituted aminomethyltetralins and their heterocyclic analogues Aralkylamine compounds Anti-hypertensive sulfonanilides Use of 1C specific compounds to treat benign prostatic hyperlasia Patent #: 5403847 InventorsAssigneeApplicationNo. 124501 filed on 09/09/1993US Classes:514/524, The cyano is bonded directly to a benzene ring514/539, Plural separated benzene rings in Z moiety514/567, Benzene ring nonionically bonded514/603, Nitrogen in Q514/620, The nitrogen in R is an amino nitrogen attached indirectly to a ring by acyclic bonding514/654, The chain consists of two or more carbons which are unsubtituted or have acyclic hydrocarbyl substituents only514/655, The aryl ring or aryl ring system and amino nitrogen are bonded directly to the same acylic carbon, which carbon additionally has only hydrogen or acyclic hydrocarbyl substituents bonded directly thereto558/422, The nitrogen is attached indirectly to a benzene ring by acyclic nonionic bonding560/37, The nitrogen is not bonded directly to a ring562/442, Nitrogen not bonded directly to a ring564/86, Nitrogen in substituent Q564/164, The substituent nitrogen is an amino nitrogen attached indirectly to a ring by acyclic nonionic bonding564/378, The aryl ring or ring system is polycyclo564/387The aryl ring or ring system is polycycloExaminersPrimary: Raymond, Richard L.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/135C07C 211/03 AbstractThis invention relates to novel aromatic amine compounds having the structure: ##STR1## where each W, Z1 and Z2 is independently H, C1 -C6 alkyl, C1 -C6 alkoxy, OH, F, Cl, Br, I, NO2, CN, SO2 NHR3, NR42, CONR32, COR5 ; where each R1 and R2 is independently H, C1 -C6 straight or branched chain alkyl or phenyl; where each X and Y is independently CH2, NR4, S, S=O, SO2 ; where n is 0, 1 or 2; where each p and q is independently 1 or 2; where R3 is H, C1 -C6 straight or branched chain alkyl or phenyl; where R4 is H, C1 -C6 straight or branched chain alkyl or COR3 ; and where R5 is H, C1 -C6 straight or branched chain alkyl or phenyl, C1 -C6 straight or branched chain alkoxy or OH.In addition the invention includes using such compounds for the treatment of benign prostatic hyperplasia, lowering intraocular pressure and inhibiting cholesterol synthesis.Other References
Field of SearchThe nitrogen is attached indirectly to a benzene ring by acyclic nonionic bondingThe nitrogen is not bonded directly to a ring Nitrogen not bonded directly to a ring Nitrogen in substituent Q The substituent nitrogen is an amino nitrogen attached indirectly to a ring by acyclic nonionic bonding The aryl ring or ring system is polycyclo The aryl ring or ring system is polycyclo The cyano is bonded directly to a benzene ring Plural separated benzene rings in Z moiety Benzene ring nonionically bonded Nitrogen in Q The nitrogen in R is an amino nitrogen attached indirectly to a ring by acyclic bonding The chain consists of two or more carbons which are unsubtituted or have acyclic hydrocarbyl substituents only The aryl ring or aryl ring system and amino nitrogen are bonded directly to the same acylic carbon, which carbon additionally has only hydrogen or acyclic hydrocarbyl substituents bonded directly thereto |
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