Multiparticulate pulsatile drug delivery system
Patent 5508040 Issued on April 16, 1996. Estimated Expiration Date: 
June 13, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 13, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesComposition comprising a therapeutic agent and a modulating agent Controlled absorption diltiazem formulations 5017381 Controlled release article with pulsatile release Diltiazem formulation Diltiazem formulations and methods of treatment Patent #: 5336504 InventorAssigneeApplicationNo. 244745 filed on 06/13/1994US Classes:424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/452, With claimed designated perfecting feature in contents (e.g., excipient, lubricant, etc.)424/453, Telescoping two piece424/489Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)ExaminersPrimary: Page, Thurman K.Assistant: Benston, William E. Jr. Attorney, Agent or FirmInternational ClassA61K 009/48AbstractA unit dosage form of capsule, tablet or the like is composed of a large number of pellets made up of two or more populations of pellets or particles. Each pellet contains a core containing the therapeutic drug and a water soluble osmotic agent. A water-permeable, water-insoluble polymer film encloses each core. Incorporated into the polymer film is a hydrophobic, water insoluble agent which alters the permeability of the polymer film. The film coating of each population of pellets differs from the coating of every other population of pellets in the dosage form in the rate at which water passes through to the core and the rate at which drug diffuses out of the core. The osmotic agent dissolves in the water, causing the pellet to swell and regulating the rate of diffusion of drug into the environment of use. As each population of pellets releases its drug into the environment sequentially, the effect is to provide a series of pulsatile administrations of the drug from a single dosage form.Field of SearchWith claimed designated perfecting feature in contents (e.g., excipient, lubricant, etc.)Capsules (e.g., of gelatin, of chocolate, etc.) Particulate form (e.g., powders, granules, beads, microcapsules, and pellets) Natural gums, resin or latex Telescoping two piece Polysaccharides (e.g., cellulose, etc.) Containing solid synthetic polymers | |
