U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Systemic administration of a therapeutic preparation

Patent 5506203 Issued on April 9, 1996. Estimated Expiration Date: Icon_subject June 23, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Dosage inhalator
Patent #: 4524769
Issued on: 06/25/1985
Inventor: Wetterlin

Dosage inhalator
Patent #: 4534345
Issued on: 08/13/1985
Inventor: Wetterlin

Drug administration
Patent #: 4548922
Issued on: 10/22/1985
Inventor: Carey ,   et al.

Indicating means for a dosage dispensing device
Patent #: 4668218
Issued on: 05/26/1987
Inventor: Virtanen

Drug administration
Patent #: 4746508
Issued on: 05/24/1988
Inventor: Carey ,   et al.

Gas administration apparatus
Patent #: 4759358
Issued on: 07/26/1988
Inventor: Gregory

Device in powder inhalators Patent #: 4907583
Issued on: 03/13/1990
Inventor: Wetterlin, et al.

Inventors

Assignee

Application

No. 265371 filed on 06/23/1994

US Classes:

514/4, With an additional active ingredient514/3, Insulin or derivative530/303Insulin; related peptides

Examiners

Primary: Schain, Howard E.
Assistant: Prickril, Benet

Attorney, Agent or Firm

Foreign Patent References

  • 0225189 EP. 11/13/1986
  • 0272097 EP. 06/13/1988
  • 0455463 EP. 11/13/1991
  • 8807820 SE. 11/13/1986
  • 1527605 GB. 10/13/1976
  • WO88/09163 WO. 12/13/1988
  • WO94/07514 WO. 04/13/1994

International Classes

A61K 038/28
C07K 014/62

Foreign Application Priority Data

1993-06-24 SE

Abstract

A method of treating a patient in need of insulin treatment, including the steps of introducing into the lower respiratory tract of the patient an effective amount of a therapeutic preparation in the form of a dry powder containing (a) insulin and (b) an enhancer compound which enhances the absorption of insulin in the lungs of the patient.

Other References

  • Allenby et al., The Absorption of Insulin Across the Respiratory Tract of the Guinea-Pig (U), The Aerosol Society, Fourth Annual Conference 1990, pp. 129-134
  • Aungust and Rogers, Comparison of the Effects of Various Transmucosal Absorption Promotors on Buccal Insulin Delivery, Int. J. Pharm. (Netherlands), 1989, 53/3, 227-235
  • Bjork, Starch Microspheres as a Nasal Delivery System for Drugs, Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 103, 1993
  • Bjork and Edman, Degradable Starch Microspheres as a Nasal Delivery System for Insulin, Int. J. Pharm. 47:233-238, 1988
  • Brange et al., Monomeric Insulins and Their Experimental and Clinical Implications, Diabetes Care 13:923-954, 1990
  • Edman and Bjork, Routes of Delivery: Case Studies, Advanced Drug Delivery Reviews 8:165-177, 1992
  • Igawa et al., Effect of Absorption Promoters in Intranasal Administration of Human Fibroblast Interferon as a Powder Dosage Form in Rabbits, Chem. Pharm. Bull. 37:418-421, 1989
  • Komada et al., Intratracheal Delivery of Peptide and Protein Agents: Absorption from Solution and Dry Powder by Rat Lung, J. Pharm. Sci. 83:863-867, 1994
  • Lasker, The Diabetes Control and Complications Trail, N. Engl. J. Med. 329:1035-1036, 1993
  • Laube et al., Preliminary Study of the Efficacy of Insulin Aerosol Delivery by Oral Inhalation in Diabetic Patients, JAMA 269:2106-2109, 1993
  • Lee et al., Intranasal Bioavailability of Insulin Powder Formulations: Effect of Permeation Enhancer-to-Protein Ratio, J. Pharm. Sci. 80:725-729, 1991
  • Mishima et al., Studies on the Promoting Effects of Medium Chain Fatty Acid Salts on the Nasal Absorption of Insulin in Rats, J. Pharma -Dyn. 10:624-631, 1987
  • Morita et al., Effects of Various Absorption Promoters on Pulmonary Absorption of Drugs with Different Molecular Weights, Biol. Pharm. Bull. 16:269:262, 1993
  • Nagai et al., Powder Dosage Form of Insulin for Nasal Administration, J. Controlled Release 1:15-22, 1984
  • "Diabetes Mellitus", Ch. VI in Scientific American Medicine, Scientific American, Inc., Apr. 1993
  • The Diabetes Control and Complications Trail Research Group, The Effect of Intensive Treatment of Diabetes on the Development . . . Complications in Insulin-Dependent Diabetes Mellitus, N. Engl. J. Med. 329:977-86, 1993
  • Pontiroli et al., Nasal Administration of Glucagon and Human Calcitonin to Healthy Subjects: a Comparison of Powders and Spray Solutions and of Different Enhancing Agents, Eur. J. Clin. Pharmcol. 37:427-430, 1989
  • Schipper et al., Nasal Insulin Delivery with Dimethyl-ଲ-Cyclodextrin as an Absorption Enhancer in Rabbits: Powder More Effective than Liquid Formulations, Pharmaceutical Research 10:682-686, 1993
  • Selam and Charles, Devices for Insulin Administration, Diabetes Care 13:955-979, 1990
  • Touitou and Rubenstein, Targeted Enteral Delivery of Insulin to Rats, Int. J. Pharm. (Amst.), 30(2-3), 1986, 95-100
  • Wigley et al., Insulin Across Respiratory Mucosae by Aerosol Delivery, Diabetes 20:552-556, 1971
  • Zinman, Medical Intelligence--The Physiologic Replacement of Insulin, W. Engl. J. Med. 321:363-370, 198
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