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US Patent 5505983 - Spherical seed cores, spherical granules and process for production thereof
US Patent Issued on April 9, 1996
Estimated Patent Expiration Date:
October 17, 2014Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
October 17, 2014Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractPharmacologically inactive spherical seed cores comprising at least 50% by weight of microcrystalline cellulose having an average degree of polymerization of 60 to 375, wherein the spherical seed cores have an average particle size of 100 to 1000 μm, a tapped bulk density of at least 0.65 g/ml, an aspect ratio of at least 0.7, a water absorption capacity of 0.5 to 1.5 ml/g, and a friability of no more than 1%; spherical granules comprising the spherical seed cores coated with a powdery layer comprising active ingredients and having an outer layer of coating provided on the powdery layer; and a process for the production of spherical granules, comprising the steps of coating the spherical seed cores with powder comprising active ingredients using an aqueous binding solution, spraying an aqueous solution or suspension of a coating agent thereon, and drying the resulting coated granules.Other References
| InventorAssigneeApplicationNo. 325952 filed on 10/17/1994US Classes:427/2.21, Retarded or controlled-release layer produced (e.g., enteric)427/2.16, Retarded or controlled-release layer produced (e.g., enteric)427/2.19, Retarded or controlled-release layer produced (e.g., enteric)427/196, Plural direction application of coating materials or simultaneously applying particles and binder from different sources427/214Applying superposed diverse coatings or coating a coated baseField of Search427/2.16, Retarded or controlled-release layer produced (e.g., enteric)427/2.18, En masse rotating means employed (e.g., rotating pan, tumbling)427/2.19, Retarded or controlled-release layer produced (e.g., enteric)427/2.21, Retarded or controlled-release layer produced (e.g., enteric)427/196, Plural direction application of coating materials or simultaneously applying particles and binder from different sources427/214, Applying superposed diverse coatings or coating a coated base427/426Ingredients supplied separatelyExaminersPrimary: Dudash, DianaAttorney, Agent or FirmUS Patent References3146168, 3539380, 3873694, 4159345, Novel excipient and pharmaceutical composition containing the sameIssued on: 06/26/1979 Inventor: Takeo , et al.4176175, Sugar-coated solid dosage forms Issued on: 11/27/1979 Inventor: Maekawa , et al.4261971, Pharmaceutically preparation comprising a cardiac glycoside in combination with a polymer Issued on: 04/14/1981 Inventor: Appelgren , et al.4274830, Colored medicinal tablet, natural color pigment and method for using the pigment in coloring food, drug and cosmetic products Issued on: 06/23/1981 Inventor: Woznicki , et al.4302440, Easily-swallowed, powder-free and gastric-disintegrable aspirin tablet thinly-coated with hydroxypropyl methylcellulose and aqueous spray-coating preparation thereof Issued on: 11/24/1981 Inventor: John , et al.4489026, Process for preparing solid unit dosage forms of ultra-low dose drugs Issued on: 12/18/1984 Inventor: Yalkowsky4540602, Process for the preparation of activated pharmaceutical compositions Issued on: 09/10/1985 Inventor: Motoyama , et al.4623588, Controlled release composite core coated microparticles Issued on: 11/18/1986 Inventor: Nuwayser , et al.4684534, Quick-liquifying, chewable tablet Issued on: 08/04/1987 Inventor: Valentine4744987, Coprocessed microcrystalline cellulose and calcium carbonate composition and its preparation Issued on: 05/17/1988 Inventor: Mehra , et al.4867985, Spheroids Issued on: 09/19/1989 Inventor: Heafield , et al.4900558, Sustained release ibuprofen formulation including a core of ibuprofen and a microcrystalline cellulose and a covering of acrylic polymer and hydroxylated cellulose derivative Issued on: 02/13/1990 Inventor: Barry, et al.4917900, Controlled release formulations containing zidovudine Issued on: 04/17/1990 Inventor: Jones, et al.5026560, Spherical granules having core and their production Issued on: 06/25/1991 Inventor: Makino, et al.5112621, Sustained release pharmaceutical composition of diltiazem Issued on: 05/12/1992 Inventor: Stevens, et al.5188836Sustained release formulations Issued on: 02/23/1993 Inventor: Muhammad, et al. Foreign Patent References
International ClassesA61K 047/38A61K 009/14 B05D 001/34 Foreign Application Priority Data1990-04-18 JP |
