Patent References 3551554 Vehicle composition containing 1-substituted azacycloheptan-2-ones Bandage for transdermally administering scopolamine to prevent nausea Vehicle composition containing 1-substituted azacycloalkan-2-ones Penetration enhancers for transdermal drug delivery of systemic agents Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone Soft patch Medical device for pulsatile transdermal delivery of biologically active agents Transdermal multipolymer drug delivery system Process for the production of an adhesive plaster InventorsAssigneeApplicationNo. 186925 filed on 04/01/1994US Classes:424/448, Pressure sensitive adhesive means424/449Transdermal or percutaneousExaminersPrimary: Phelan, D. GabrielleAttorney, Agent or FirmInternational ClassA61F 013/00AbstractDisclosed herein is a medicinal adhesive for percutaneous administration of a drug consisting of a support (backing layer), an adhesive layer comprising an oil-soluble drug, an adhesive resin, a penetration enhancer, a water-absorptive material and a lenitive agent, and a separate liner, charaterized in that the adhesive layer has a laminated structure having 2 to 5 layers and each layer has different water absorption capacities, and the drug is a oil-soluble, non-steroidal drug. For the adhesive of the present invention, the lowest layer which is to be contacted with the skin has the lowest water absorption capacity and the most upper layer in contact with the support has the highest water absorption capacity, or vice versa.Other References
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