U.S. patents available from 1976 to present.
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Positional sequencing by hybridization

Patent 5503980 Issued on April 2, 1996. Estimated Expiration Date: Icon_subject October 17, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Nucleic acid sequence determination by multiple mixed oligonucleotide probes
Patent #: 5002867
Issued on: 03/26/1991
Inventor: Macevicz

Method for the simultaneous determination of DNA sequence variations at a large number of sites, and a kit suitable therefor
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Issued on: 11/26/1991
Inventor: Vijg, et al.

Method of staining nucleic acids detected by non-radioactive labelling and kit of reactants for carrying out the method
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Issued on: 12/17/1991
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Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
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Target-dependent synthesis of an artificial gene for the synthesis of a replicatable RNA
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Inventor: Kramer, et al.

DNA sequencing using fluorescence background electroblotting membrane
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Process for DNA sequencing using oligonucleotide bank
Patent #: 5114839
Issued on: 05/19/1992
Inventor: Blocker

Methods and compositions for the detection of sequences in selected DNA molecules
Patent #: 5137806
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Inventor: LeMaistre, et al.

Multiplex analysis of DNA
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Inventor: Church, et al.

Method of sequencing of genomes by hybridization of oligonucleotide probes Patent #: 5202231
Issued on: 04/13/1993
Inventor: Drmanac, et al.

Inventor

Assignee

Application

No. 322526 filed on 10/17/1994

US Classes:

435/6, Involving nucleic acid435/91.1, Polynucleotide (e.g., nucleic acid, oligonucleotide, etc.)435/91.52, Involving a ligase (6.)536/23.1, DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)536/24.32Probes for detection of microbial nucleotide sequences

Examiners

Primary: Jones, W. Gary
Assistant: Tran, Pablo N.

Attorney, Agent or Firm

Foreign Patent References

  • 0392546 EP. 12/13/1990
  • WO89/10977 WO. 11/13/1989

International Classes

C07H 021/04
C12P 019/34
C12Q 001/68

Abstract

This invention is directed to methods for determining a nucleotide sequence of a nucleic acid using positional sequencing by hybridization, and to the creation of nucleic acids probes which may be used with these methods. This invention is also directed to diagnostic aids for analyzing the nucleic acid composition and content of biological samples, including samples derived from medical and agricultural sources.

Other References

  • Wahlberg et al. Mol. Cell. Probes 4(4):285-297, 1990
  • Yu et al. Doklady Akademii Nauk SSSR, 303(6)1508-1511, 1988 (English translation)
  • Khrapko et al. FEBS 256(1,2) 118-112, 1989
  • Drmanac et al. Journal of Biomolecular Structure & Dynamics 8(5):1085-1102, 1991
  • Matthews et al. Analytical Biochem. 169:1-25, 1988
  • Article, "Optical Properties of Specific Complexes Between Complementary Oligoribonucleotides", Robert B. Gennis et al, Biochemistry, vol. 9, No. 24, 1970
  • Article, "DNA Sequencing By Hybridization: 100 Bases Read By a Non-gel-based Method", Zakina Strezoska, Proc. Natl. Acad. Sci. USA, vol. 88, pp. 10089-10093, Nov. 1991
  • Article, "Improved Chips for Sequencing by Hybridization", P. A. Pevzner, et al., Journal of Biomolecular Structure & Dynamics, vol. 9, Issue No. 2, pp. 63-69 1991
  • Article, "A Method for DNA Sequencing By Hybridization with Oligonucleotide Matrix", K. R. Khrapko et al, DNA Sequence-J. DNA Sequencing and Mapping, vol. 1, pp. 375-388, 1991
  • Article, "Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide", Peter E. Neilsen et al, Science, vol. 254, Dec. 1991
  • Article, "Parallel Analysis of Oligodeoxyribonucleotide (oligonucleotide) interactions. I. Analysis of Factors Influencing Oligonucleotide Duplex Formation", Uwe Maskos et al, Nucleic Acids Research, vol. 20, No. 7, pp. 1675-1678, 1992
  • Article, "Analyzing and Comparing Nucleic Acid Sequences by Hybridization to Arrays of Oligonucleotides: Evaluation Using Experimental Models", E. M. Southern, Genomics 13, 1008-1017, 1992
  • Article, "Oligonucleotide Hybridisations of Glass Supports: A Novel Linker for Oligonucleotide Syntheis and Hybridisation Properties of Oligonucleotides Synthesised in Situ", Uwe Maskos, Nucleic Acids Research, vol. 20, No. 7, pp. 1679-1684, 1992
  • Article, "Encoded Combinatorial Chemistry", Sydney Brenner, Proc. Natl. Acad. Sci. USA, vol. 89, pp. 5381-5383, Jun. 1992
  • Article, "Report on the Sequencing by Hybridization Workshop", C. R. Cantor, Genomics 13, 1378-1383, 199
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