U.S. patents available from 1976 to present.
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Readily available konjac glucomannan as a sustained release excipient

Patent 5486364 Issued on January 23, 1996. Estimated Expiration Date: Icon_subject August 15, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3928322

Gel system
Patent #: 4746528
Issued on: 05/24/1988
Inventor: Prest ,   et al.

Thermo-irreversible edible gels of glucomannan and xanthan gums
Patent #: 4894250
Issued on: 01/16/1990
Inventor: Musson, et al.

Directly compressible sustained release excipient
Patent #: 4994276
Issued on: 02/19/1991
Inventor: Baichwal, et al.

Prolonged release drug tablet formulations Patent #: 5096714
Issued on: 03/17/1992
Inventor: Kuhrts

Inventors

Assignee

Application

No. 290457 filed on 08/15/1994

US Classes:

424/488, Polysaccharides (e.g., cellulose, etc.)424/409, Solid as carrier or diluent424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/468, Sustained or differential release type514/960, SIGNIFICANT, TABLET FORMULATION (E.G., DESIGNATED EXCIPIENT, DISINTEGRANT, GLYDENT OR LUBRICANT, ETC.)514/961Binder therefor

Examiners

Primary: Webman, Edward J.

Attorney, Agent or Firm

Foreign Patent References

  • 2531339 BE. 02/13/1984
  • 0253541 EP 01/13/1988
  • 2523446 FR 09/13/1983
  • 901111 FR 03/13/1985
  • 57185216 JP. 11/13/1988
  • 443819 JP. 08/13/1992

International Classes

A61K 009/22
A61K 009/10
A61K 047/36

Abstract

A solid dosage form, such as a pharmaceutical tablet, containing a rapidly hydratable konjac glucomannan sustained release excipient such as clarified konjac, cryogenically ground konjac and plasticized konjac. The method of making the tablets by compressing excipient and pharmaceutically active ingredient as dry powders.

Other References

  • "Formulating For Controlled Release with Methocel Cellulose Ethers", Bulletin of Dow Chemical Company (1987)
  • Chronotherapeutic Release from Direct Compression Tablets Using Heterodisperse Polysaccharides, Stainforth, et al. extended Abstract of Paper presented at AAPS Meeting, Washington, D.C. pp. 18-21, 1991
  • Preparatin and Dissolution Characteristics of Pullulan Tablets Ohta, et al., Kobunshi Ronbunshu, vol. 42, No. 11, pp. 817-823 (Nov. 1985)
  • Konjac Flour and Properties and Applications, Richard J. Tye, Food Technology (Mar. 1991
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