Analysis based on flow restriction
Patent 5486335 Issued on January 23, 1996. Estimated Expiration Date: 
April 24, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 24, 2015. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3799742 Liquid transport device and method Electrode-containing device with capillary transport between electrodes Capillary transport device having speed and meniscus control means Capillary flow control Laboratory slide Polysilicon binding assay support and methods Biological diagnostic device and method of use Silicon semiconductor wafer for analyzing micronic biological samples Method for forming a miniaturized biological assembly InventorsAssigneeApplicationNo. 427493 filed on 04/24/1995US Classes:422/55, Structured visual or optical indicator, per se422/58, In holder or container having special form422/61, Test package or kit422/68.1, Means for analyzing liquid or solid sample422/73, With coagulometer for agglutination, clotting, or prothrombin, or for particle (e.g., cell, etc.) counting, or volume or characteristics determination435/7.2, Involving a micro-organism or cell membrane bound antigen or cell membrane bound receptor or cell membrane bound antibody or microbial lysate435/7.21, Animal cell435/287.1, Including measuring or testing435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid435/288.7, Including optical measuring or testing means436/164, OPTICAL RESULT436/524, Carrier is inorganic436/809Multifield plates or multicontainer arraysExaminersPrimary: Warden, Robert J.Assistant: Tran, Hien Attorney, Agent or FirmForeign Patent References
International ClassG01N 021/00AbstractDisclosed are devices and methods for detecting the presence of a preselected analyte in a fluid sample. The invention provides a device comprising a solid substrate, typically on the order of a few millimeters thick and approximately a 0.2 to 2.0 centimeters square, microfabricated to define a sample inlet port and a mesoscale flow system. A sample is passed through the mesoscale flow system, and the restriction or blockage of flow through the flow system is detected as a positive indication of the presence of the analyte. The mesoscale flow system includes in one embodiment a primary sample flow channel extending from the inlet port, and a fractal region, in fluid communication with the flow channel, comprising bifurcations leading to plural secondary flow channels. The device may be adapted for operation in conjunction with a pump, for example, to induce flow of a sample through the flow system. A detector may also be provided for detecting analyte induced changes in flow properties in the mesoscale flow system. The devices of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, such as viruses.Other References
Field of SearchStructured visual or optical indicator, per seIn holder or container having special form Test package or kit Means for analyzing liquid or solid sample With coagulometer for agglutination, clotting, or prothrombin, or for particle (e.g., cell, etc.) counting, or volume or characteristics determination MAINTAINING BLOOD OR SPERM IN A PHYSIOLOGICALLY ACTIVE STATE OR COMPOSITIONS THEREOF OR THEREFOR OR METHODS OF IN VITRO BLOOD CELL SEPARATION OR TREATMENT Involving a micro-organism or cell membrane bound antigen or cell membrane bound receptor or cell membrane bound antibody or microbial lysate Animal cell Involving nucleic acid OPTICAL RESULT Volumetric liquid transfer BIOSPECIFIC LIGAND BINDING ASSAY Carrier is inorganic Multifield plates or multicontainer arrays Fluid containers (e.g., cells or cuvettes) |
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