Therapeutic and diagnostic use of modified polymeric microcapsules
Patent 5484584 Issued on January 16, 1996. Estimated Expiration Date: 
January 16, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 16, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3891570 Preparation of small bio-compatible microspheres Method of magnetic separation of cells and the like, and microspheres for use therein Polyglutaraldehyde synthesis and protein bonding substrates Microencapsulation process Polyacrolein microspheres Process for preparation of microspheres and modification of release rate of core material Method of preparing microspheres for intravascular delivery Process for the production of polyacrolein microspheres and grafted microspheres Microspheres for incorporation of therapeutic substances and methods of preparation thereof InventorsAssigneeApplicationNo. 916348 filed on 07/17/1992US Classes:424/1.29, Coated, impregnated, or colloidal particulate (e.g., microcapsule, micro-sphere, micro-aggregate, macro-aggregate)264/4.3, With treatment subsequent to solid wall formation (e.g., coating, hardening, etc.)264/4.33, Microcapsule wall derived from synthetic polymer424/9.4, X-ray contrast imaging agent (e.g., computed tomography, angiography, etc.)424/9.45, Halogenated benzene ring containing424/491, Containing proteins and derivatives424/497, Containing solid synthetic polymers424/499, Contains proteins or derivative or polysaccharides or derivative424/501, Contains solid synthetic resin427/213.31, With post-treatment of encapsulant or encapsulating material (e.g., further coating, hardening, etc.)428/402.21Solid-walled microcapsule from synthetic polymerExaminersPrimary: Geist, GaryAssistant: Harris, C. Attorney, Agent or FirmForeign Patent References
International ClassesA61K 051/00B01J 013/02 B32B 005/16 AbstractThe present invention relates to a highly efficient method of preparing modified microcapsules exhibiting selective targeting. These microcapsules are suitable for encapsulation surface attachment of therapeutic and diagnostic agents. In one aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the providing improved targeting of encapsulated agents to specific tissue cells. Examples include encapsulation of radiodiagnostic agents in 1 μm capsules to provide improved opacification and encapsulation of cytotoxic agents in 100 μm capsules for chemoembolization procedures. The microcapsules are suitable for attachment of a wide range of targeting agents, including antibodies, steroids and drugs, which may be attached to the microcapsule polymer before or after formation of suitably sized microcapsules. The invention also includes microcapsules surface modified with hydroxyl groups. Various agents such as estrone may be attached to the microcapsules and effectively targeted to selected organs.Other References
Field of SearchContaining solid synthetic polymersContains proteins or derivative or polysaccharides or derivative Contains solid synthetic resin Containing proteins and derivatives Coated, impregnated, or colloidal particulate (e.g., microcapsule, micro-sphere, micro-aggregate, macro-aggregate) Solid-walled microcapsule from synthetic polymer With post-treatment of encapsulant or encapsulating material (e.g., further coating, hardening, etc.) With treatment subsequent to solid wall formation (e.g., coating, hardening, etc.) Microcapsule wall derived from synthetic polymer | |
