Compositions and method comprising aminoalcohol derivatives as membrane penetration enhancers for physiological active agents
Patent 5482965 Issued on January 9, 1996. Estimated Expiration Date: 
September 3, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 3, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesInventorApplicationNo. 115772 filed on 09/03/1993US Classes:514/452, Plural ring oxygens in the hetero ring514/478, N-C(=X)-X-C containing514/479, With an additional active ingredient514/546, ZC(=O)OY, wherein Z is an acyclic radical bonded to the C=O by a carbon and Y is an organic radical bonded to the oxygen by a carbon514/547, Compound contains two or more C(=O)O groups514/552, Z contains an unbroken chain of at least seven carbon atoms bonded directly to the C(=O) group514/625, R is acyclic514/629, R is hydrogen or a lower saturated alkyl of less than seven carbons514/946, PENETRANT OR ABSORBENT (ENHANCES PENETRATION INTO SUBJECT TREATED)514/947Topical applicationExaminersPrimary: Criares, T. J.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/27A61K 031/335 A61K 031/22 A61K 031/225 A61K 031/23 A61K 031/16 AbstractA method and compositions for enhancing absorption of topically administered physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for local or systemic use, comprising a therapeutically effective amount of a pharmaceutically active agent and a non-toxic, effective amount of penetration enhancing agent of the formula I or a physiologically acceptable salt thereof: ##STR1## wherein: R1, R2, R3 and R4 are as defined herein.Field of SearchFacial moisturizerCarboxylic acid ester N-C(=X)-X-C containing With an additional active ingredient Plural ring oxygens in the hetero ring ZC(=O)OY, wherein Z is an acyclic radical bonded to the C=O by a carbon and Y is an organic radical bonded to the oxygen by a carbon Compound contains two or more C(=O)O groups Z contains an unbroken chain of at least seven carbon atoms bonded directly to the C(=O) group R is acyclic R is hydrogen or a lower saturated alkyl of less than seven carbons PENETRANT OR ABSORBENT (ENHANCES PENETRATION INTO SUBJECT TREATED) Topical application | |
