Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
Patent 5478577 Issued on December 26, 1995. Estimated Expiration Date: 
November 23, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 23, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesSuppression of withdrawal symptoms in opioid-induced tolerance or dependence Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance Sustained release pharmaceutical composition Patent #: 5330766 InventorsAssigneeApplicationNo. 156468 filed on 11/23/1993US Classes:424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/456, Gelatin424/457, Sustained or differential release424/468, Sustained or differential release type424/490Coated (e.g., microcapsules)ExaminersPrimary: Page, Thurman K.Assistant: Benston, William E. Jr. Attorney, Agent or FirmInternational ClassA61K 009/14AbstractPatients are treated with 24-hour oral sustained release opioid formulations which upon administration quickly release an effective portion of the opioid contained therein such that there is an initially more rapid opioid release so that the minimum effective analgesic concentration of the opioid can be more quickly achieved. In the method, the formulations are designed to provide a relatively large peak to trough concentration of the opioid, rather than a flattened serum concentration curve.Other References
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