U.S. patents available from 1976 to present.
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Diagnostic uses of hydrazinoadenosines

Patent 5477857 Issued on December 26, 1995. Estimated Expiration Date: Icon_subject September 10, 2013. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

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Inventors

Application

No. 119774 filed on 09/10/1993

US Classes:

600/431, Detectable material placed in body514/46, Adenosine or derivative514/263.4, Nitrogen bonded directly to ring carbon of the purine ring system (e.g., adenine, etc.)600/508Heart

Examiners

Primary: Rosenbaum, C. Fred
Assistant: Smith, Chalin

Attorney, Agent or Firm

International Class

A61B 006/00

Abstract

The present invention discloses a method for measuring myocardial function in a mammal in need of such measurement by:a) administering 0.01-15 μg/kg/min of a compound of the formula: ##STR1## where R1 is hydrogen or the group ##STR2## where R3 and R4 are the same or different and are hydrogen, C1 to C12 linear or branched alkyl, C3 to C7 cycloalkyl, C6 to C10 aryl unsubstituted or substituted with C1 to C6 linear or branched alkyl, C1 to C6 linear or branched alkoxy, nitro, amino, amino substituted with at least one C1 to C6 linear or branched alkyl or phenyl, C2 to C10 aralkyl, C4 to C8 heteroaryl wherein said heteroatom is nitrogen, phosphorous, sulfur or oxygen, and R2 is hydrogen, or taken together with R5, forms a chemical bond, and R is a monosaccharide radical selected from the group consisting essentially of glucose, fructose, ribose, 2-deoxyribose, mannose, galactose, xylose and arabinose; and then:b) performing a technique on said mammal to detect myocardial function.This invention relates to the use of hydrazinoadenosines in the diagnosis of myocardial dysfunction by electrophysiologic analysis or by imaging the vasculature of the heart, especially under conditions that simulate stress.

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