Compositions for topical application to skin, hair and nails

Patent 5476661 Issued on December 19, 1995. Estimated Expiration Date:

October 21, 2014. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Amide derivative and external medicament comprising same
Patent #: 4778823
Issued on: 10/18/1988
Inventor: Kawamata , et al.

External skin care preparation
Patent #: 4985547
Issued on: 01/15/1991
Inventor: Yano, et al.

Amide derivatives and dermatologic preparations containing the same
Patent #: 5175321
Issued on: 12/29/1992
Inventor: Ohashi, et al.

Cosmetic composition
Patent #: 5198210
Issued on: 03/30/1993
Inventor: Critchley, et al.

Synthetic pseudoceramide and cosmetic compositions thereof Patent #: 5206020
Issued on: 04/27/1993
Inventor: Critchley, et al.

Inventors

Assignee

Elizabeth Arden Co., Division of Conopco, Inc.

Application

No. 326994 filed on 10/21/1994

US Classes:

424/401, Cosmetic, antiperspirant, dentifrice424/61, MANICURE OR PEDICURE COMPOSITIONS424/70.1, LIVE HAIR OR SCALP TREATING COMPOSITIONS (NONTHERAPEUTIC)514/844, COSMETIC, FACIAL514/846, Cleansing cream or lotion514/847Facial moisturizer

Examiners

Primary: Venkat, Jyothsna

Attorney, Agent or Firm

Mitelman; Rimma

Foreign Patent References

0512814 EP. 11/13/1992
WO91/19479 WO. 12/13/1991

International Classes

A61K 007/48
A61K 007/06
A61K 007/04

Abstract

Compositions for treating skin, hair and nails which contain 25-hydroxycalciferol in combination with a lipid ingredient. The compositions avoid the toxic effects of 1,25-dihydroxycalciferol, yet attain keratinocyte differentiation and provide additional benefits. Also disclosed is a method of improving or preventing the appearance of wrinkled, flaky, aged, photodamaged skin by applying to skin a composition containing in a cosmetically acceptable vehicle 25-hydroxycalciferol and a lipid ingredient.

Other References

Pillai et al., "Epidermal Vitamin D Metabolism, Function, and Regulation", Advances In Lipid Research, vol. 24, (1991), pp. 321-341
Bikle et al., "1,25-Dihydroxyvitamin D₃ Production by Human Keratinocytes", The Journal of Clinical Investigation, Inc., vol. 78, (Aug. 1986), pp. 557-566
Pillai et al., "1,25-Dihydroxyvitamin D Production and Receptor Binding in Human Keratinocytes Varies with Differentiation", The Journal of Biological Chemistry, vol. 263, No. 11, (Apr. 15, 1988), pp. 5390-5395
Hashimoto et al., "Growth-inhibitory Effects of 1,25-Dihydroxyvitamin D₃ on Normal and Psoriatic Keratinocytes", British Journal of Dermatology, (1990), vol. 123, pp. 93-98
Morimoto et al., "Topical Administration of 1,25-Dihydroxyvitamin D₃ for Psoriasis: Report of Five Cases", Calcif Tissue Int., vol. 38, (1986), pp. 119-122
MacLaughlin et al., "Cultured Human Keratinocyctes Cannot Metabolize Vitamin D₃ to 25-hydroxyvitamin D₃ ", Federation of European Biochemical Societies, vol. 282, No. 2, (May 1991), pp. 409-411
Holick, M. F. in "Cutaneous Aging" (edited by A. Kligman), pp. 223-246, Univ. of Tokyo Press, Tokyo, 1988
Bikle et al., "Squamous Carcinoma Cell Lines Produce 1,25-Dihydroxyvitamin D, but Fail to Respond to Its Prodifferentiating Effect", The Society for Investigative Dermatology, Inc., (1991), p. 435
Okazaki et al., reported in "Role of Ceramide as a Lipid Mediator of 1଱,25-Dihydroxyvitamin D₃ -induced HL-60 Cell Differentiation", The Journal of Biological Chemistry, vol. 265, No. 26, Sep. 15, 1990, pp. 15823-15831
Calcif Tissue Int, vol. 38 pp. 119-122 (1986